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Pravastatin is available as a 10 mg, 20 mg, 40 mg, and 80 mg oral tablet.

Pravastatin is a statin that is used to:

• Lower the risk of heart or blood vessel problems (e.g., heart attack, stroke) in adults at risk for heart problems
• Lower “bad” cholesterol and triglyceride levels in certain adults
• Lower “bad” cholesterol levels in children age 8 years and older with heterozygous familial hypercholesterolemia (HeFH)

Pravastatin is a statin. It works by blocking a protein in your liver that makes cholesterol. This lowers the amount of “bad” cholesterol (called low-density lipoprotein, or LDL) in your blood. Pravastatin might also help raise your “good” cholesterol (called high-density lipoprotein, or HDL) levels and lower your triglyceride levels. As a result, Pravastatin helps lower the risk of coronary artery disease, heart attack, and stroke.

Pravastatin is typically taken at dose ranges from 10 mg to 80 mg by mouth once per day. Your provider will change your dose depending on different factors, such as your cholesterol levels, kidney function, side effects that you’re having, or other medications you might be taking.

Pravastatin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication for the following:

• Hypersensitivity to any component of this medication.
  Active liver disease or unexplained, persistent elevations of serum transaminases
• Women who are pregnant or may become pregnant.
  Nursing mothers

Common side effects of Pravastatin:

• Muscle, joint, or bone pain
• Upper respiratory infection
• Chest pain
• Nausea or vomiting
• Tiredness
• Headache

Serious side effects are rare with Pravastatin. Contact your healthcare provider immediately if you experience any of the following.

• Severe muscle damage (rhabdomyolysis): dark brown urine, severe muscle weakness or pain, fever, tiredness
• Liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine

The following medications may interact with Pravastatin:

• Concomitant lipid-lowering therapies: use with fibrates or lipid-modifying doses (≥1 g/day) of niacin increases the risk of adverse skeletal muscle
• effects. Caution should be used when prescribing with Pravastatin
• Cyclosporine: combination increases exposure. Limit Pravastatin to 20 mg once daily
• Clarithromycin: combination increases exposure. Limit Pravastatin to 40 mg once daily

Various FDA-approved generic manufacturers

Pravastatin may cause harm to your unborn baby. Discontinue Pravastatin when pregnancy is recognized.

• Pravachol