Posaconazole Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Posaconazole DR
    Generic for Noxafil
    30 delayed release tablets $171.6 USD
    Save $1471.50
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Do you need a prescription for posaconazole?

Yes, posaconazole is only available with a valid physician Rx.

How much is posaconazole without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase posaconazole, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for posaconazole in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a posaconazole savings card?

Yes. Save up to 90% on your posaconazole with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a posaconazole coupon provider in the US?

No. Now Patient does not provide posaconazole coupons or FREE posaconazole samples.

Do you accept commercial, Medicare or Medicaid coverage for posaconazole in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much posaconazole?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using posaconazole. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much posaconazole. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

US brand name of posaconazole and manufacturer

Posaconazole is available in the US under the brand name Noxafil. It is manufactured by Merck & Co., Inc.

UK brand name of posaconazole and manufacturer

Posaconazole is available in the UK under the brand name Noxafil. It is also manufactured by Merck & Co., Inc.

Prescription requirement for posaconazole

Posaconazole is a prescription medication and requires a prescription from a healthcare provider.

FDA approval of posaconazole

Posaconazole has received FDA approval for the prevention of invasive Aspergillus and Candida infections in patients who are at high risk due to being severely immunocompromised.

Active ingredient of posaconazole and mechanism of action

Posaconazole is a triazole antifungal medication. It works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. By disrupting the integrity of the fungal cell membrane, posaconazole prevents the growth and replication of various fungal pathogens.

Uses of posaconazole

Posaconazole is primarily used for the prophylaxis of invasive fungal infections in individuals with weakened immune systems, such as those undergoing hematopoietic stem cell transplantation who have graft-versus-host disease (GVHD), and patients with hematological malignancies receiving chemotherapy, or those with prolonged neutropenia. It is effective against various fungal pathogens, including Aspergillus and Candida species. Posaconazole also shows good results for the treatment of fungal infections refractory to other antifungal therapy.

Forms of posaconazole

Posaconazole is available in different dosage forms, including posaconazole oral suspension, delayed-release tablets, and intravenous (IV) injection formulations.

Dosage of posaconazole

The dosage of posaconazole will depend on several factors, including the specific infection being treated, the patient’s weight, and their overall health condition. Posaconazole may be taken during or right after a full meal or liquid nutritional supplement. It may also be consumed with an acidic beverage. Posaconazole has an average half-life of 35 hours. It is important to follow the dosage instructions provided by your healthcare provider.

Contraindications and warnings for posaconazole

  • Posaconazole may have drug interactions with other medications, including certain antacids, anti-arrhythmic drugs, and immunosuppressants. It is important to inform your healthcare provider about all the medications you are taking
  • Posaconazole can cause hepatic toxicity, including severe liver damage. Regular monitoring of liver function is recommended during treatment
  • Posaconazole should not be used during pregnancy unless the potential benefits outweigh the risks. It is not recommended for use while breastfeeding
  • Tell your doctor if you are allergic to posaconazole or other azole antifungal medications such as fluconazole, itraconazole, ketoconazole, or voriconazole
  • Tell your doctor if you have an irregular heartbeat, problems with blood circulation, or low calcium, magnesium, or potassium blood levels

Side effects of posaconazole

In clinical trials common side effects of posaconazole may include nausea, diarrhea, headache, and abdominal pain. Serious adverse events are rare but can include severe allergic reactions, liver problems, and changes in heart rhythm (QT prolongation). If you experience any severe or persistent adverse effects, contact a healthcare professional.

Interactions with other drugs

Posaconazole can interact with several medications, including certain antacids, anti-arrhythmic drugs, calcium channel blockers, CYP3A4 enzyme inhibitors, immunosuppressants, cimetidine, cyclosporine, rifamycins (such as rifabutin), ritonavir, drugs to treat seizures (such as phenytoin), certain benzodiazepines (such as midazolam), sirolimus, tacrolimus and antifungal agents. It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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