Key facts about Polyethylene Glycol (PEG)
What dosages is Polyethylene Glycol (PEG) available in?
polyethylene glycol (PEG) is available as an oral solution that contains polyethylene glycol 3350 (227.1 grams), sodium sulfate (21.5 grams), sodium bicarbonate (6.36 grams), sodium chloride
(5.53 grams), potassium chloride (2.82 grams) in a one gallon packet.
What is Polyethylene Glycol (PEG) used for?
polyethylene glycol (PEG) is an osmotic laxative and is used to cleanse the colon to prepare for a colonoscopy, and cleansing the colon to prepare for barium enema x-ray examination (polyethylene glycol (PEG), Colyte, Gavilyte-C, and certain generic preps only).
How does Polyethylene Glycol (PEG) work?
polyethylene glycol (PEG) is a combination medication that contains polyethylene glycol 3350 (PEG), an osmotic laxative that cleanses out your bowels by pulling water into your colon and causing you to have very watery diarrhea to get rid of the stools, and electrolytes to prevent you from losing too, many bodily fluids and electrolytes.
How do I take Polyethylene Glycol (PEG)?
polyethylene glycol (PEG) dosing will vary depending on the brand of medication that your provider prescribes. Please read the directions on the label carefully before using.
Is it safe for me to take Polyethylene Glycol (PEG)?
polyethylene glycol (PEG) is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a gastrointestinal (GI) obstruction, ileus, or gastric retention, a bowel perforation, toxic colitis or toxic megacolon, or a known allergy or hypersensitivity to components of polyethylene glycol (PEG).
Polyethylene Glycol (PEG) Common Side Effects
Common side effects of polyethylene glycol (PEG) include:
- Nausea
- Vomiting
- Feeling very full in your stomach
- Bloating
- Stomach cramps
- Anal irritation
Polyethylene Glycol (PEG) Serious Side Effects
Serious side effects are rare with polyethylene glycol (PEG). Contact your healthcare provider immediately if you experience any of the following.
- Kidney problems: weakness, drowsiness, urinating less than normal, swelling of ankles, feet, and legs
- Electrolyte imbalance (changes in body fluid and blood salts): vomiting, stomach cramps, dizziness, urinating less than normal, fast heart rate, fast breathing, headache, fainting, or lack of energy
- Colon ulcers: severe stomach pain, rectal bleeding
- Heartbeat problems: Feeling anxious, a fluttering in the chest, chest pain, dizziness, feeling light-headed
- Seizures
- Choking
Effects of other drugs, drug classes and over-the-counter products on Polyethylene Glycol (PEG)
The following medications may interact with polyethylene glycol (PEG):
- diuretics – May affect renal function
- ACE inhibitors – May affect renal function
- ARBs – May affect renal function
- NSAIDs – May affect renal function
- Avoid concomitant stimulant laxatives such as bisacodyl or sodium picosulfate
- Oral drugs administered within 1hr of start of polyethylene glycol (PEG) may not be absorbed
Who makes Polyethylene Glycol (PEG)?
Various FDA-approved generic manufacturers
Is Polyethylene Glycol (PEG) safe in pregnancy?
It is not known if polyethylene glycol (PEG) will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.













