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Plenvu is the brand name for polyethylene glycol 3350, sodium ascorbate, sodium sulfate, ascorbic
acid, sodium chloride and potassium chloride and is available as an oral solution.

Plenvu is available as an oral solution.

Plenvu is an osmotic laxative and is used for the following:

• Cleansing the colon to prepare for colonoscopy
• Cleansing the colon to prepare for barium enema x-ray examination (Golytely, Colyte, Gavilyte-C, and certain generic preps only)

Plenvu is a combination medication that contains:

• Polyethylene glycol 3350 (PEG), an osmotic laxative that cleanses out your bowels by pulling water into your colon and causing you to have very watery diarrhea to get rid of the stools. Electrolytes, to prevent you from losing too much body fluids and electrolytes

Plenvu is dosed as follows:

• The dosing for PEG 3350/electrolytes bowel prep varies depending on the brand of medication that your provider prescribes. Please read the directions on the label carefully before using
• Golytely, Colyte, Nulytely, Gavilyte-C, Gavilyte-G,

Gavilyte-N, and generic PEG 3350 with electrolytes:

• One dose is needed for a complete bowel prep. Prepare the dose by following the directions on the container. After it’s mixed, a full dose should contain about 4 L of solution. It’s typically taken the evening before the procedure
• Adults: After mixing the solution, drink 8 fl oz by mouth every 10 minutes until gone, or until you start to have watery stool that’s clear in color and without any solids
• Children 6 months or older (Nulytely, Gavilyte N, and certain generics only): After mixing the solution, your child should drink at the rate of 25 mL/kg per hour by mouth until they start to have watery stool that’s clear in color and without any solids

Moviprep and generic PEG 3350 with electrolytes:

• Two doses of Moviprep (or generic PEG 3350 with electrolytes) are needed for a complete bowel prep. Prepare each dose by following the directions on the container. After it’s mixed, each dose should contain about 1 L of solution. Drink 8 fl oz of the Moviprep mixture (or generic PEG 3350 with electrolytes mixture) by mouth every 15 minutes until gone. This should take about 1 hour
• Two-day dosing (preferred): Drink dose 1 the evening before colonoscopy. To complete your dose, fill the empty container half way with clear liquid and drink until gone. Drink dose 2 the morning of colonoscopy (about 12 hours after starting dose 1 and at least 3.5 hours before your procedure). Again, to complete your dose, fill the empty container half way with clear liquid and drink until gone
• One-day dosing: Drink dose 1 at least 3.5 hours before bedtime on the evening before colonoscopy. Drink dose 2 at least 1.5 hours after starting dose 1. After dose 2, fill the empty container to the fill line with clear liquid and drink until gone before going to bed

Plenvu:

• Two doses of Plenvu are needed for a complete bowel prep. Prepare each dose by following the directions on the container. After it’s mixed, each dose of Plenvu should contain about a half liter of solution. Drink the Plenvu mixture by mouth, over 30 minutes, until gone. To complete your dose, fill the empty container to the fill line with clear liquid and drink over 30 minutes, until gone
• Two-day dosing (preferred): Drink dose 1 on the evening before colonoscopy (between 4pm and 8pm). Drink dose 2 on the morning of colonoscopy (about 12 hours after dose 1)
• One-day dosing: Drink dose 1 on the morning of colonoscopy (between 3am and 7am). Drink dose 2 at least 2 hours after starting dose 1

Plenvu is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Gastrointestinal (GI) obstruction
• Bowel perforation
• Gastric retention
• Ileus
• Toxic colitis or toxic megacolon
• Hypersensitivity to any ingredient in Plenvu

Common side effects of Plenvu:

• Nausea
• Vomiting
• Feeling very full in your stomach
• Bloating
• Stomach cramps
• Anal irritation
• Shivering (Moviprep)
• Trouble sleeping (Moviprep)
• More hungry and thirsty (Moviprep)
• Tiredness (Moviprep)

Serious side effects are rare with Plenvu. Contact your healthcare provider immediately if you experience any of the following.

• Kidney problems: weakness, drowsiness, urinating less than normal, swelling of ankles, feet, and legs
• Electrolyte imbalance (changes in body fluid and blood salts): vomiting, stomach cramps, dizziness, urinating less than normal, fast heart rate, fast breathing, headache, fainting, or lack of energy
• Colon ulcers: severe stomach pain, rectal bleeding
• Heartbeat problems: Feeling anxious, a fluttering in the chest, chest pain, dizziness, feeling light-headed
• Seizures
• Choking

The following medications may interact with Plenvu:

• Drugs that increase risk for fluid and electrolyte imbalance

Bausch Health

It is not known if Plenvu will harm your unborn baby. Plenvu should be given to a pregnant woman only if clearly needed.

• Polyethylene Glycol (PEG)