PADCEV
Used for Cancer
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Manufactured by Astellas Pharma
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PADCEV Uses, Side Effects, Interactions, Warnings & Dosing
What is PADCEV?
PADCEV is the brand name for enfortumab vedotin-ejfv and is available as an IV infusion.
What dosages is PADCEV available in?
PADCEV is available as an injection that contains 20 mg or 30 mg of enfortumab vedotin-ejfv.
What is PADCEV used for?
PADCEV V is a Nectin-4-directed antibody and microtubule inhibitor conjugate indicated:
In combination with pembrolizumab for the treatment of adult patients with locally advanced or metastatic urothelial cancer. As a single agent for the treatment of adult patients with locally advanced or metastatic urothelial cancer who: Have previously received a programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor and platinumcontaining chemotherapy, or are ineligible for cisplatin-containing chemotherapy and have previously received one or more prior lines of therapy.
How does PADCEV work?
PADCEV works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.
How do I take PADCEV?
The recommended dose of PADCEV in combination with
pembrolizumab is 1.25 mg/kg (up to a maximum dose of 125 mg) given as an intravenous infusion over 30 minutes on Days 1 and 8 of a 21-day cycle until disease progression or unacceptable toxicity. The recommended dose of PADCEV as a single agent is 1.25 mg/kg (up to a maximum dose of 125 mg) given as an intravenous infusion over 30 minutes on Days 1, 8 and 15 of a 28-day cycle until disease progression or unacceptable toxicity.
Is it safe for me to take PADCEV?
PADCEV is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
PADCEV Common Side Effects
Common side effects of PADCEV when used alone:
- Increased sugar (glucose) in the blood
- Changes in liver and kidney function tests
- Decreased white blood cell, red blood cell, and platelet counts
- Rash
- Tiredness
- Numbness or tingling in your hands or feet
- Decreased protein (albumin), sodium, and phosphate in the blood
- Hair loss
- Decreased appetite
- Diarrhea
- Nausea
- Itching
- Increased uric acid in the blood
- Dry eye
- Change in sense of taste
- Constipation
- Increased lipase (a test done to check your pancreas)
PADCEV Serious Side Effects
Serious side effects are rare with PADCEV. Contact your healthcare provider immediately if you experience any of the following.
- Skin reactions
- High blood sugar (hyperglycemia)
- Lung problems
- Nerve problems
- Eye problems
- Leakage of PADCEV out of your vein into the tissues around your infusion site (extravasation)
Effects of other drugs, drug classes and over-the-counter products on PADCEV
The following medications may interact with PADCEV:
- Concomitant use of dual P-gp and strong CYP3A4 inhibitors with PADCEV may increase the exposure to monomethyl auristatin E (MMAE)
Who makes PADCEV?
Astellas Pharma
Is PADCEV safe in pregnancy?
PADCEV can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with PADCEV. Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start treatment with PADCEV.
You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of PADCEV.
Males with a female sexual partner who is able to become pregnant: If your female partner is pregnant, PADCEV can harm the unborn baby. You should use an effective method of birth control during your treatment and for at least 4 months after the last dose of PADCEV
What to do if you missed your PADCEV dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
Is PADCEV chemotherapy or immunotherapy?
Is PADCEV a targeted therapy?
How often is PADCEV given?
Is immunotherapy as harsh as chemo?
What class of drug is PADCEV?
Is PADCEV a monoclonal antibody?
What is another name for PADCEV?
Which is better chemotherapy or immunotherapy?
How much does enfortumab vedotin cost?
What is PADCEV treatment?
Is PADCEV approved by the FDA?
What is the success rate of PADCEV?
Does PADCEV extend life?
How long can you stay on panitumumab?
What are the toxicities of PADCEV?
What are the side effects of Pacdev?
Does PADCEV cause neuropathy?
How long does PADCEV prolong life?
Does PADCEV make you tired?
Does PADCEV cause hair loss?
Does PADCEV cause abdominal pain?
Is PADCEV covered by insurance?
Which chemo drug causes nerve damage?
Which treatment has the common side effect of peripheral neuropathy?
How bad can chemo neuropathy get?
Does CIPN get worse over time?
What are the long term effects of CIPN?
Is there a cure for neuropathy caused by chemotherapy?
What is the indication of PADCEV?
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