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enfortumab vedotin-ejfv

enfortumab vedotin-ejfv

Used for Cancer

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Manufactured by various FDA-approved generic manufacturers.

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This content is intended for US audiences only

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

Learn more about enfortumab vedotin-ejfv

What dosages is enfortumab vedotin-ejfv available in?

What dosages is enfortumab vedotin-ejfv available in?

enfortumab vedotin-ejfv is available as an injection that contains 20 mg or 30 mg of enfortumab vedotin-ejfv.

What is enfortumab vedotin-ejfv used for?

What is enfortumab vedotin-ejfv used for?

enfortumab vedotin-ejfv V is a Nectin-4-directed antibody and microtubule inhibitor conjugate indicated:

In combination with pembrolizumab for the treatment of adult patients with locally advanced or metastatic urothelial cancer. As a single agent for the treatment of adult patients with locally advanced or metastatic urothelial cancer who: Have previously received a programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor and platinumcontaining chemotherapy, or are ineligible for cisplatin-containing chemotherapy and have previously received one or more prior lines of therapy.

How does enfortumab vedotin-ejfv work?

How does enfortumab vedotin-ejfv work?

enfortumab vedotin-ejfv works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

How do I take enfortumab vedotin-ejfv?

How do I take enfortumab vedotin-ejfv?

The recommended dose of enfortumab vedotin-ejfv in combination with
pembrolizumab is 1.25 mg/kg (up to a maximum dose of 125 mg) given as an intravenous infusion over 30 minutes on Days 1 and 8 of a 21-day cycle until disease progression or unacceptable toxicity. The recommended dose of enfortumab vedotin-ejfv as a single agent is 1.25 mg/kg (up to a maximum dose of 125 mg) given as an intravenous infusion over 30 minutes on Days 1, 8 and 15 of a 28-day cycle until disease progression or unacceptable toxicity.

Is it safe for me to take enfortumab vedotin-ejfv?

Is it safe for me to take enfortumab vedotin-ejfv?

enfortumab vedotin-ejfv is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

enfortumab vedotin-ejfv Common Side Effects

enfortumab vedotin-ejfv Common Side Effects

Common side effects of enfortumab vedotin-ejfv when used alone:

  • Increased sugar (glucose) in the blood
  • Changes in liver and kidney function tests
  • Decreased white blood cell, red blood cell, and platelet counts
  • Rash
  • Tiredness
  • Numbness or tingling in your hands or feet
  • Decreased protein (albumin), sodium, and phosphate in the blood
  • Hair loss
  • Decreased appetite
  • Diarrhea
  • Nausea
  • Itching
  • Increased uric acid in the blood
  • Dry eye
  • Change in sense of taste
  • Constipation
  • Increased lipase (a test done to check your pancreas)
enfortumab vedotin-ejfv Serious Side Effects

enfortumab vedotin-ejfv Serious Side Effects

Serious side effects are rare with enfortumab vedotin-ejfv. Contact your healthcare provider immediately if you experience any of the following.

  • Skin reactions
  • High blood sugar (hyperglycemia)
  • Lung problems
  • Nerve problems
  • Eye problems
  • Leakage of enfortumab vedotin-ejfv out of your vein into the tissues around your infusion site (extravasation)
Effects of other drugs, drug classes and over-the-counter products on enfortumab vedotin-ejfv

Effects of other drugs, drug classes and over-the-counter products on enfortumab vedotin-ejfv

The following medications may interact with enfortumab vedotin-ejfv:

  • Concomitant use of dual P-gp and strong CYP3A4 inhibitors with enfortumab vedotin-ejfv may increase the exposure to monomethyl auristatin E (MMAE)
Who makes enfortumab vedotin-ejfv?

Who makes enfortumab vedotin-ejfv?

Various FDA-approved generic manufacturers

Is enfortumab vedotin-ejfv safe in pregnancy?

Is enfortumab vedotin-ejfv safe in pregnancy?

enfortumab vedotin-ejfv can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with enfortumab vedotin-ejfv. Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start treatment with enfortumab vedotin-ejfv.
You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of enfortumab vedotin-ejfv.

Males with a female sexual partner who is able to become pregnant: If your female partner is pregnant, enfortumab vedotin-ejfv can harm the unborn baby. You should use an effective method of birth control during your treatment and for at least 4 months after the last dose of enfortumab vedotin-ejfv

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What to do if you missed your enfortumab vedotin-ejfv dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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