Used for Asthma

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Manufactured by GlaxoSmithKline

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NUCALA Uses, Side Effects, Interactions, Warnings & Dosing

What is NUCALA?

What is NUCALA?

NUCALA is the brand name for mepolizumab and is available as an injection for subcutaneous use.

What dosages is NUCALA available in?

What dosages is NUCALA available in?

NUCALA is available as a 40 mg/0.4 ml and 100 mg/ml injection for subcutaneous use.

What is NUCALA used for?

What is NUCALA used for?

NUCALA is an interleukin antagonist and is used for the following:

  • Add-on maintenance treatment for severe asthma
  • Add-on maintenance treatment for chronic rhinosinusitis with nasal polyps
  • Eosinophilic granulomatosis with polyangiitis (EGPA; swelling of the blood vessels)
  • Hypereosinophilic syndrome (HES; high eosinophils in the blood)
How does NUCALA work?

How does NUCALA work?

NUCALA is an interleukin antagonist. It blocks interleukin-5 (IL-5), which is a protein that normally makes immune cells called eosinophils. High levels of eosinophils in the body cause inflammation. And, inflammation plays a role in asthma and certain other conditions. By blocking IL-5, NUCALA lowers eosinophil levels in the body. This is thought to lower inflammation to help with symptoms, such as pain, swelling, or difficulty breathing (for people with asthma).

How do I take NUCALA?

How do I take NUCALA?

This medication is injected under the skin in your thigh, stomach, or back of the upper arms. The dose depends on what condition you’re using NUCALA for and your age

Severe asthma

  • People 12 years and older: The typical dose is 100 mg injected under the skin once every month.
  • Children 6 to 11 years old: The typical dose is 40 mg injected under the skin once every month.

Chronic rhinosinusitis with nasal polyps

  • People 18 years and older: The typical dose is 100 mg injected under the skin once every month
  • EGPA (adults only) or HES (people 12 years and older)
  • The typical dose is 300 mg injected under the skin once every month. The dose is given as three separate 100 mg injections, given one right after the other
Is it safe for me to take NUCALA?

Is it safe for me to take NUCALA?

NUCALA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

  • Hypersensitivity reactions (e.g., anaphylaxis, angioedema, bronchospasm, hypotension, urticaria, rash) have occurred after administration of NUCALA. Discontinue NUCALA in the event of a hypersensitivity
  • Do not use to treat acute bronchospasm or status asthmaticus
  • Herpes zoster infections have occurred in patients receiving NUCALA. Consider vaccination if medically appropriate
  • Do not discontinue systemic or inhaled corticosteroids abruptly upon initiation of therapy with NUCALA
  • Decrease corticosteroids gradually, if appropriate
  • Treat patients with pre-existing helminth infections before therapy with NUCALA. If patients become infected while receiving treatment with NUCALA and do not respond to anti-helminth treatment, discontinue NUCALA until parasitic infection resolve
NUCALA Common Side Effects

NUCALA Common Side Effects

Common side effects of NUCALA:

  • Headache
  • Injection-site reactions
  • Back pain
  • Fatigue
  • Throat pain
  • Joint pain
NUCALA Serious Side Effects

NUCALA Serious Side Effects

Serious side effects are rare with NUCALA. Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reactions: hives; wheezing; difficulty breathing; swelling of face, mouth, tongue, or throat
Effects of other drugs, drug classes and over-the-counter products on NUCALA

Effects of other drugs, drug classes and over-the-counter products on NUCALA

  • Formal drug interaction trials have not been performed with NUCALA. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes NUCALA?

Who makes NUCALA?


Is NUCALA safe in pregnancy?

Is NUCALA safe in pregnancy?

The data on the use of NUCALA during pregnancy is insufficient to inform on drug-associated risk. However, potential effects on a fetus are likely to be greater during the second and third trimester of pregnancy. If you become pregnant while receiving NUCALA, talk to your healthcare provider.


What to do if you missed your NUCALA dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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