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Novolog is the brand name for insulin aspart and is available as an injection for subcutaneous or IV use.

Novolog is available as a vial, cartridge, FlexTouch pen and FlexPen that contains 100 units/ml.

Novolog is an insulin and is used to treat the following:

• Type 1 diabetes in adults and children
• Type 2 diabetes in adults

Novolog is an insulin, which is a natural hormone your body normally makes to lower glucose (sugar) levels in the blood. Insulin helps your body absorb sugar from your bloodstream after you eat a meal to use for energy. Insulin also stops your liver from making sugar.

Your healthcare provider will work with you to find the dose that works best for you. Your dose depends on many things, such as whether you have Type 1 or Type 2 diabetes, your blood sugar levels and how they change with insulin, and how you’re injecting the medication (under the skin, into the vein, using an insulin pump).

• For injections under the skin: Inject Novolog under the skin in the stomach, thigh, upper arm, or buttocks area within 5 to 10 minutes before a meal
• For injections through the vein: Novolog can be given as an injection or slow infusion into the vein by a healthcare provider
• For continuous insulin pumps: Use the insulin pump according to your provider’s instructions. Follow the directions from your insulin pump manufacturer to set up and use the pump

Novolog is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have symptoms of hypoglycemia.

Common side effects of Novolog:

• Severely low blood sugar
• Headache
• Accidental injury
• Nausea
• Diarrhea
• Muscles slow to react
• Severely low blood sugar
• Fungal nail infection
• Impairment of your senses
• Urinary tract infection
• Sinus infection
• Chest pain
• Stomach pain
• Headache
• Skin problems

Serious side effects are rare with Novolog. Contact your healthcare provider immediately if you experience any of the following.

• Severely low blood sugar: dizziness, shakiness, feeling confused, feeling irritable or anxious, feeling faint, sweating, extreme hunger, not able to think clearly
• Ketoacidosis (high ketone levels in the blood): nausea, vomiting, stomach pain, tiredness, thirsty, dry mouth, fruity breath, trouble breathing
• Severely low potassium levels: weakness, muscle cramps or twitches, constipation, abnormal heartbeat, tiredness, trouble breathing
• Severe allergic reactions: rash; hives; swelling of face, tongue, and throat; trouble breathing

The following medications may interact with Novolog:

• Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g. octreotide), and sulfonamide antibiotics
• Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics, corticosteroids, danazol, diuretics estrogens, glucagon, isoniazid, niacin, oral contraceptives phenothiazines, progestogens (e.g., in oral contraceptives) protease inhibitors, somatropin, sympathomimetic agents (e.g. albuterol, epinephrine, terbutaline), and thyroid hormones
• Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine
• Drugs that may blunt the signs and symptoms of hypoglycemia: beta-blockers, clonidine, guanethidine, and reserpine

Novo Nordisk Inc.

Published studies with Novolog used during pregnancy have not reported an association between its use and the induction of major birth defects, miscarriage, or adverse maternal or fetal outcomes. If you become pregnant while receiving Novolog, talk to your healthcare provider.

• Insulin Aspart