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Nortriptyline is available as a 10 mg, 25 mg, 50 mg, and 75 mg oral capsule and a 10 mg/5 ml oral solution.

Nortriptyline is a tricyclic antidepressant that is used to treat depression.

Nortriptyline is a tricyclic antidepressant (TCA). It helps improve your mood by adjusting the levels of serotonin, norepinephrine, and other similar chemicals in your brain.

Nortriptyline is typically dosed at 25 mg by mouth three or four times daily. Doses above 150 mg per day are not recommended.

Nortriptyline is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are in the acute recovery period after myocardial infarction or have taken an MAOI in the past 14 days.

Common side effects of Nortriptyline:

• Blurred vision
• Dry mouth
• Nausea
• Vomiting
• Loss of appetite
• Numbness in the hands or feet
• High blood pressure
• Rash
• Itching

Serious side effects are rare with Nortriptyline. Contact your healthcare provider immediately if you experience any of the following.

• Allergic reaction
• Worsening depression
• Suicidal thoughts and behaviors
• Seizure
• Chest pain
• Shortness of breath
• Serotonin syndrome: Fast heart rate, sweating, muscle stiffness or spasms, fever, confusion
• Withdrawal: Nausea, vomiting, mood swings, “brain-zaps”

The following medications may interact with Nortriptyline:

• Administration of reserpine during therapy with a tricyclic antidepressant has been shown to produce a “stimulating” effect in some depressed patients
• Close supervision and careful adjustment of the dosage are required when Nortriptyline is used with other anticholinergic drugs and sympathomimetic drugs
• Concurrent administration of cimetidine and tricyclic antidepressants can produce clinically significant increases in the plasma concentrations of the tricyclic
• antidepressant. The patient should be informed that the response to alcohol may be exaggerated
• A case of significant hypoglycemia has been reported in a type II diabetic patient maintained on chlorpropamide (250 mg/day), after the addition of Nortriptyline (125 mg/day)

Various FDA-approved generic manufacturers

Safe use of Nortriptyline during pregnancy and lactation has not been established; therefore, when the drug is administered to pregnant patients, nursing mothers, or women of childbearing potential, the potential benefits must be weighed against the
possible hazards.

• Pamelor