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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

naltrexone Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is naltrexone available in?

What dosages is naltrexone available in?

naltrexone is available as a 50 mg oral tablet.

What is naltrexone used for?

What is naltrexone used for?

naltrexone is an opioid antagonist that is used to treat:

  • Alcohol use disorder
  • Opioid use disorder
How does naltrexone work?

How does naltrexone work?

naltrexone is an opioid antagonist. It blocks opioid receptors (signaling proteins) in your body and prevents you from feeling the effects of opioid medications and alcohol.

How do I take naltrexone?

How do I take naltrexone?

For Alcohol use disorder: The typical recommended dose is 50 mg by mouth every day for up to 3 months. For Opioid use disorder: The typical starting dose is 25 mg by mouth every day. If you don’t experience signs of withdrawal, your provider might raise the dose to 50 mg every day.

Is it safe for me to take naltrexone?

Is it safe for me to take naltrexone?

naltrexone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. naltrexone is contraindicated in:

  • Patients receiving opioid analgesics
    Patients currently dependent on opioids, including those currently maintained on opiate agonists (e.g., methadone) or partial agonists (e.g., buprenorphine)
  • Patients in acute opioid withdrawal (see WARNINGS)
  • Any individual who has failed the naloxone challenge test or who has a positive urine screen for opioids
  • Any individual with a history of sensitivity to naltrexone or any other components of this product. It is not known if there is any cross-sensitivity with naloxone or the
    phenanthrene containing opioids
naltrexone Common Side Effects

naltrexone Common Side Effects

Common side effects of naltrexone:

  • Nausea
  • Headache
  • Dizziness
  • Nervousness
  • Tiredness
  • Trouble sleeping
  • Anxiety
  • Stomach pain or cramps
  • Joint and muscle pain
naltrexone Serious Side Effects

naltrexone Serious Side Effects

Serious side effects are rare with naltrexone. Serious Side Effects
Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts or actions
  • Liver injury: dark urine, feeling very tired, sudden nausea and vomiting, stomach pain on the upper right side, clay-colored stool, yellowing of the skin or whites of the eyes
  • Lung problems (eosinophilic pneumonia): trouble breathing, chest pain, fever, cough
Effects of other drugs, drug classes and over-the-counter products on naltrexone

Effects of other drugs, drug classes and over-the-counter products on naltrexone

The following medications may interact with naltrexone:

  • naltrexone antagonizes the effects of opioid-containing medicines, such as cough and cold remedies, antidiarrheal preparations, and opioid analgesics
Who makes naltrexone?

Who makes naltrexone?

Various FDA-approved generic manufacturers

Is naltrexone safe in pregnancy?

Is naltrexone safe in pregnancy?

It is not known if naltrexone will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.


What to do if you missed your naltrexone dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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