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Midazolam is available as a single-dose nasal spray unit containing 5 mg Midazolam per 0.1 mL solution.

Midazolam is a benzodiazepine and is used to treat seizure attacks in people with epilepsy who are 12 years of age and older.

Midazolam is a benzodiazepine. It’s thought to slow down activity in your brain to help stop seizures.

Midazolam is dosed as follows:

• Adults and children 12 years of age and older: Spray 1 dose (5 mg) into one nostril. After 10 minutes, if the seizure isn’t controlled, spray a second dose into the other nostril. Don’t use more than 2 doses of Midazolam to treat a seizure attack
• It isn’t recommended to use Midazolam more than once every 3 days or more than 5 times in a month. Talk to your provider if you or your child has a seizure attack more often than this because it means that your seizures aren’t well controlled. Your provider will need to adjust your daily seizure medications so that the attacks happen less often

Midazolam is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Patients with hypersensitivity to Midazolam
• Patients with acute narrow-angle glaucoma

Common side effects of Midazolam:

• Drowsiness
• Nasal discomfort
• Headache
• Throat irritation
• Runny nose

Serious side effects are rare with Midazolam. Contact your healthcare provider immediately if you experience any of the following.

• Withdrawal: unusual involuntary movements, muscle pain and stiffness, shaky hands, stomach upset, anxiety, panic attacks, changes in mood or behavior, fast heart beat, more seizures
• Accidentally taking too much (overdose): trouble breathing, extreme sleepiness, difficulty thinking straight, confusion, weakness, bluish fingernails and lips, hard time walking or moving normally, coma
  Thoughts of hurting yourself or suicide

The following medications may interact with Midazolam:

• CYP3A4 Inhibitors: Avoid co-administration of Midazolam with moderate or strong CYP3A4 inhibitors. Midazolam should be used with caution when co-administered with mild CYP3A4 inhibitors
• Opioids: Risk of respiratory depression is increased.
• Other CNS Depressants: May increase the risks of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect

Various FDA-approved generic manufacturers

Taking Midazolam late in pregnancy may cause your baby to have symptoms of sedation (breathing problems, sluggishness, low muscle tone), and/or withdrawal symptoms (jitteriness, irritability, restlessness, shaking, excessive crying, feeding problems). Tell your healthcare provider right away if you become pregnant or think you are pregnant during
treatment with Midazolam. If you become pregnant while using Midazolam, talk to your healthcare provider about registering with the North American Antiepileptic Drug (NAAED) Pregnancy Registry. You can register by
calling 1-888-233-2334. For more information about the registry, go to AED pregnancy registry The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy.

• Nayzilam