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Liothyronine is available as a 5 mcg, 25 mcg, and 50 mcg oral tablet.

Liothyronine is a triiodothyronine (T3) used for hypothyroidism, thyroid cancer (with radiation and surgery), and as a thyroid suppression test.

Liothyronine is a synthetic version of the T3 thyroid hormone made by your thyroid gland. Thyroid hormones have important functions like controlling metabolism, body temperature, heart rate, and more. When the amount of hormone is too low, taking thyroid replacement hormones can bring your levels back to normal.

Liothyronine is typically taken by mouth once daily and individual dosage according to your response and laboratory findings.

Liothyronine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have uncorrected adrenal cortical insufficiency.

Common side effects of Liothyronine include:

• Shakiness
• Fast or irregular heart beat
• Hair loss
• Fever
• Sweating
• Weight loss
• Weak muscles
• Fatigue
• Anxiety
• Trouble sleeping
• Increased appetite
• Trouble breathing

Serious side effects are rare with Liothyronine. Contact your healthcare provider immediately if you experience any of the following.

• Heart attack

The following medications may interact with Liothyronine:

• Bile Acid Sequestrants such as colesevelam, cholestyramine, and colestipol and Ion Exchange Resins such as kayexalate and sevelamer – May decrease thyroid hormones absorption. Administer Liothyronine at least 4 hours prior to these drugs or monitor TSH levels
• Clofibrate, estrogen-containing oral contraceptives, estrogens (oral), methadone, 5-Fluorouracil, mitotane, and tamoxifen – May increase serum thyroxine-binding globulin (TBG) concentration
• androgens / anabolic steroids, asparaginase, glucocorticoids, slow-release nicotinic acid – These drugs may decrease serum TBG concentration
• Phenobarbital and rifampin – May decrease the levels and effects of thyroid hormones

Various FDA-approved generic manufacturers

Liothyronine use during pregnancy has not shown any increased rates of major birth defects or miscarriages. However, you should talk to your healthcare provider before taking this medication if you are pregnant.

• Cytomel