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Linaclotide is available as a 72 mcg, 145 mcg, and 290 mcg oral capsule.

• Linaclotide is a GC-C agonist and is used for the following:
• Irritable bowel syndrome with constipation (IBS-C) in adults
• Chronic idiopathic constipation (CIC) in adults
• Functional constipation (FC) in children

Linaclotide is a guanylate cyclase-C (GC-C) agonist. GC-C is a protein that works in the intestines. Linaclotide turns on GC-C, which helps raise the amount of fluid in your intestines and speed up the movement of food through your gut. These actions help you have regular bowel movements and possibly relieve belly pain.

The dose of Linaclotide depends on which type of chronic constipation you have.

Adults

• Irritable bowel syndrome with constipation (IBS-C): The typical dose is 290 mcg by mouth once daily
• Chronic idiopathic constipation (CIC): The typical dose is 72 mcg or 145 mcg by mouth once daily

Children ages 6 to 17 years old

• Functional constipation (FC): The typical dose is 72 mcg by mouth once daily

Linaclotide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. This medication should not be used in:

• Patients less than 2 years of age.
• Patients with known or suspected mechanical gastrointestinal obstruction

Common side effects of Linaclotide:

• Diarrhea
• Stomach pain
• Gas
• Bloating and feeling full in the belly

Serious side effects are rare with Linaclotide. Contact your healthcare provider immediately if you experience any of the following.

Severe diarrhea
Bloody stools or black stools that look like tar
Dehydration: confusion, dizziness, fainting, racing heart

• There are no major drug interactions listed for Linaclotide. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Various FDA-approved generic manufacturers

It is not known if Linaclotide will harm your unborn baby. If you become pregnant while receiving Linaclotide, talk to your healthcare provider.

• Linzess