View LINZESS savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or LINZESS Patient Assistance Program.

Programs are suitable for individuals who want to buy LINZESS without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by AbbVie Inc.

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

Drug savings programs

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    Rx Advantage Card

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    Save up to 90%

  • Available

    Canadian Prescription Savings

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  • Available

    Drug Coupons

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    Pay as little as $0

  • Available

    Patient Assistance Programs

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about LINZESS

What is LINZESS?

What is LINZESS?

LINZESS is the brand name for linaclotide and is available as an oral capsule.

What dosages is LINZESS available in?

What dosages is LINZESS available in?

LINZESS is available as a 72 mcg, 145 mcg, and 290 mcg oral capsule.

What is LINZESS used for?

What is LINZESS used for?

  • LINZESS is a GC-C agonist and is used for the following:
  • Irritable bowel syndrome with constipation (IBS-C) in adults
  • Chronic idiopathic constipation (CIC) in adults
  • Functional constipation (FC) in children
How does LINZESS work?

How does LINZESS work?

LINZESS is a guanylate cyclase-C (GC-C) agonist. GC-C is a protein that works in the intestines. LINZESS turns on GC-C, which helps raise the amount of fluid in your intestines and speed up the movement of food through your gut. These actions help you have regular bowel movements and possibly relieve belly pain.

How do I take LINZESS?

How do I take LINZESS?

The dose of LINZESS depends on which type of chronic constipation you have.


  • Irritable bowel syndrome with constipation (IBS-C): The typical dose is 290 mcg by mouth once daily
  • Chronic idiopathic constipation (CIC): The typical dose is 72 mcg or 145 mcg by mouth once daily

Children ages 6 to 17 years old

  • Functional constipation (FC): The typical dose is 72 mcg by mouth once daily
Is it safe for me to take LINZESS?

Is it safe for me to take LINZESS?

LINZESS is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. This medication should not be used in:

  • Patients less than 2 years of age.
  • Patients with known or suspected mechanical gastrointestinal obstruction
LINZESS Common Side Effects

LINZESS Common Side Effects

Common side effects of LINZESS:

  • Diarrhea
  • Stomach pain
  • Gas
  • Bloating and feeling full in the belly
LINZESS Serious Side Effects

LINZESS Serious Side Effects

Serious side effects are rare with LINZESS. Contact your healthcare provider immediately if you experience any of the following.

Severe diarrhea
Bloody stools or black stools that look like tar
Dehydration: confusion, dizziness, fainting, racing heart

Effects of other drugs, drug classes and over-the-counter products on LINZESS

Effects of other drugs, drug classes and over-the-counter products on LINZESS

  • There are no major drug interactions listed for LINZESS. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes LINZESS?

Who makes LINZESS?

AbbVie Inc.

Is LINZESS safe in pregnancy?

Is LINZESS safe in pregnancy?

It is not known if LINZESS will harm your unborn baby. If you become pregnant while receiving LINZESS, talk to your healthcare provider.


What to do if you missed your LINZESS dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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