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Laronidase is available as a 2.9 mg/5 mL vial for IV infusion.

Laronidase is an enzyme replacement therapy and is used for the following:

• Certain forms of mucopolysaccharidosis type I (MPS I):
• Hurler and Hurler-Scheie forms
• Scheie form with moderate-to-severe symptoms

Laronidase works by replacing an enzyme that’s missing in some forms of mucopolysaccharidosis type I (MPS I). People with MPS I don’t have enough of or are missing an enzyme that’s needed to break down long chains of sugar molecules, which can lead to cell, tissue, or organ damage.

Laronidase is only available as an intravenous (IV) infusion that’s administered by a healthcare provider. The recommended dose is 0.58 mg/kg of body weight, given as an infusion into the vein once a week. Your provider will determine the appropriate dose based on your body weight and health conditions.

Laronidase is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Laronidase:

• Infusion reactions (pyrexia, chills, blood
• pressure increased, tachycardia, and oxygen saturation decreased).
• Rash
• Upper respiratory tract infection
• Flushing

Serious side effects are rare with Laronidase. Contact your healthcare provider immediately if you experience any of the following.

• Allergic reaction
• Acute respiratory failure

• There are no major drug interactions listed for Laronidase. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Various FDA-approved generic manufacturers

It is not known if Laronidase will harm your unborn baby. Tell your healthcare provider if you become pregnant while taking Laronidase. An MPS I Registry has been established and pregnant women with MPS I should be encouraged to enroll in the pregnancy sub-registry. For more information, visit www.registrynxt.com or call 1-800-745-4447 ext. 15500.

• Aldurazyme