glyburide/metformin
Used for Type 2 Diabetes
NowPatient helps you obtain your glyburide/metformin prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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glyburide/metformin key facts
What dosages is glyburide/metformin available in?
glyburide/metformin is available as an oral tablet that contains 2.5 mg of glyburide and 500 mg of metformin or 5 mg of glyburide and 500 mg of metformin.
What is glyburide/metformin used for?
glyburide/metformin is a sulfonylurea/biguanide and is used to treat type 2 diabetes.
How does glyburide/metformin work?
glyburide/metformin is a combination of two diabetes medications that work together to lower the blood sugar in your body. Glyburide is a sulfonylurea that lowers your blood sugar by stimulating (waking up) your pancreas to release insulin. Metformin is a biguanide that lowers the amount of sugar your liver makes, lowers the amount of sugar your stomach absorbs, and helps you respond better to insulin.
How do I take glyburide/metformin?
glyburide/metformin is dosed depending on your previous dose of glyburide or metformin.
The typical starting dose is 1.25 mg/250 mg (glyburide/metformin) by mouth once or twice daily with meals.
If you are currently taking glyburide (or another sulfonylurea) or metformin, the typical starting dose is 2.5 mg/500 mg (glyburide/metformin) or 5 mg/500 mg (glyburide/metformin) by mouth twice daily with meals.
The maximum dose is 20 mg/2000 mg (glyburide/metformin) by mouth daily.
Is it safe for me to take glyburide/metformin?
glyburide/metformin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have severe renal impairment (eGFR below 30 mL/min/1.73 m2), a hypersensitivity to metformin or glyburide, acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma, or are currently taking bosentan.
glyburide/metformin Common Side Effects
Common side effects of glyburide/metformin include:
- Low blood sugar
- Diarrhea
- Headache
- Nausea or vomiting
- Stomach pain
- Dizziness
glyburide/metformin Serious Side Effects
Serious side effects are rare with glyburide/metformin. Contact your healthcare provider immediately if you experience any of the following.
Lactic acidosis (buildup of lactic acid): unusual muscle pain, difficulty breathing, unusual sleepiness, stomach pain, feeling cold in hands or feet, low blood pressure, slow heart rate, very weak or tired
Dangerously low blood sugar: coma, seizures, or other problems that affect the brain, nerves, and spinal cord
Hemolytic anemia (destruction of your red blood cells): pale or lack of skin color, yellowing of skin or eyes, dark-colored urine, weakness, dizziness, confusion
Effects of other drugs, drug classes and over-the-counter products on glyburide/metformin
The following medications may interact with glyburide/metformin:
- Carbonic anhydrase inhibitors may increase risk of lactic acidosis.
- Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine) may increase the accumulation of metformin.
- Alcohol can potentiate the effect of metformin on lactate metabolism.
Who makes glyburide/metformin?
Various FDA-approved generic manufacturers
Is glyburide/metformin safe in pregnancy?
glyburide/metformin has not shown any drug associated risks for major birth defects, miscarriage, or adverse maternal outcomes from a small number of published studies and postmarketing experience with glyburide/metformin use in pregnancy over decades. However, sulfonylureas (including glipizide) cross the placenta and have been associated with neonatal adverse reactions such as hypoglycemia. Therefore, glyburide/metformin should be discontinued at least two weeks before expected delivery.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my glyburide/metformin prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your glyburide/metformin prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient glyburide/metformin savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient glyburide/metformin savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for glyburide/metformin | Canadian Prescription Savings* for glyburide/metformin | glyburide/metformin Drug Coupon* | glyburide/metformin Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of glyburide/metformin?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for glyburide/metformin | Canadian Prescription Savings* for glyburide/metformin | glyburide/metformin Drug Coupon* | glyburide/metformin Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the glyburide/metformin savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the glyburide/metformin drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for glyburide/metformin, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the glyburide/metformin prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, glyburide/metformin is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed glyburide/metformin for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the glyburide/metformin prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the glyburide/metformin prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for glyburide/metformin
If you are having trouble paying for your glyburide/metformin medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for glyburide/metformin you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- glyburide/metformin is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers glyburide/metformin
- If glyburide/metformin is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for glyburide/metformin
If you are having trouble paying for your glyburide/metformin medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for glyburide/metformin you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers glyburide/metformin
- If glyburide/metformin is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for glyburide/metformin
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your glyburide/metformin treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for glyburide/metformin you will need to meet the following criteria:
- You must be currently insured and have coverage for glyburide/metformin
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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