GLUCOVANCE
Used for Type 2 Diabetes
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Manufactured by Merck & Co., Inc.
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GLUCOVANCE Uses, Side Effects, Interactions, Warnings & Dosing
What is GLUCOVANCE?
GLUCOVANCE is the brand name for glyburide/metformin and is available as an oral tablet.
What dosages is GLUCOVANCE available in?
GLUCOVANCE is available as an oral tablet that contains 2.5 mg of glyburide and 500 mg of metformin or 5 mg of glyburide and 500 mg of metformin.
What is GLUCOVANCE used for?
GLUCOVANCE is a sulfonylurea/biguanide and is used to treat type 2 diabetes.
How does GLUCOVANCE work?
GLUCOVANCE is a combination of two diabetes medications that work together to lower the blood sugar in your body. Glyburide is a sulfonylurea that lowers your blood sugar by stimulating (waking up) your pancreas to release insulin. Metformin is a biguanide that lowers the amount of sugar your liver makes, lowers the amount of sugar your stomach absorbs, and helps you respond better to insulin.
How do I take GLUCOVANCE?
GLUCOVANCE is dosed depending on your previous dose of glyburide or metformin.
The typical starting dose is 1.25 mg/250 mg (glyburide/metformin) by mouth once or twice daily with meals.
If you are currently taking glyburide (or another sulfonylurea) or metformin, the typical starting dose is 2.5 mg/500 mg (glyburide/metformin) or 5 mg/500 mg (glyburide/metformin) by mouth twice daily with meals.
The maximum dose is 20 mg/2000 mg (glyburide/metformin) by mouth daily.
Is it safe for me to take GLUCOVANCE?
GLUCOVANCE is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have severe renal impairment (eGFR below 30 mL/min/1.73 m2), a hypersensitivity to metformin or glyburide, acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma, or are currently taking bosentan.
GLUCOVANCE Common Side Effects
Common side effects of GLUCOVANCE include:
- Low blood sugar
- Diarrhea
- Headache
- Nausea or vomiting
- Stomach pain
- Dizziness
GLUCOVANCE Serious Side Effects
Serious side effects are rare with GLUCOVANCE. Contact your healthcare provider immediately if you experience any of the following.
Lactic acidosis (buildup of lactic acid): unusual muscle pain, difficulty breathing, unusual sleepiness, stomach pain, feeling cold in hands or feet, low blood pressure, slow heart rate, very weak or tired
Dangerously low blood sugar: coma, seizures, or other problems that affect the brain, nerves, and spinal cord
Hemolytic anemia (destruction of your red blood cells): pale or lack of skin color, yellowing of skin or eyes, dark-colored urine, weakness, dizziness, confusion
Effects of other drugs, drug classes and over-the-counter products on GLUCOVANCE
The following medications may interact with GLUCOVANCE:
- Carbonic anhydrase inhibitors may increase risk of lactic acidosis.
- Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine) may increase the accumulation of metformin.
- Alcohol can potentiate the effect of metformin on lactate metabolism.
Who makes GLUCOVANCE?
Merck & Co., Inc.
Is GLUCOVANCE safe in pregnancy?
GLUCOVANCE has not shown any drug associated risks for major birth defects, miscarriage, or adverse maternal outcomes from a small number of published studies and postmarketing experience with GLUCOVANCE use in pregnancy over decades. However, sulfonylureas (including glipizide) cross the placenta and have been associated with neonatal adverse reactions such as hypoglycemia. Therefore, GLUCOVANCE should be discontinued at least two weeks before expected delivery.
What to do if you missed your GLUCOVANCE dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Tips
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
Is glucovance the same as metformin?
Is glyburide being discontinued?
What is the best brand of metformin for diabetes?
What can I take naturally instead of metformin?
What is the strongest metformin?
What are the three brand name of metformin?
What is the use of Glucovance?
What is the side effect of glucovance?
How much does glucovance cost?
Is glyburide hard on the kidneys?
When should I stop taking glucovance?
What is the generic for Glucovance?
Which is safer glyburide or metformin?
What is the safest drug for type 2 diabetes?
Why is glyburide a high risk medication?
What is the other name for Glucovance?
Who should not use glyburide?
When should you not take glyburide?
Does glucoven work?
Should you eat before or after taking glucovance?
Does glucovance cause weight gain?
When is the best time of day to take glyburide?
What are the side effect of glucovance?
Can you drink alcohol with glucovance?
What part of the day is best to take metformin?
Do glyburide cause weight gain?
Should I take glyburide in the morning or at night?
Can you take metformin and glyburide at the same time?
What are the side effects of diamide 5mg 500mg?
Should glyburide be taken on an empty stomach?
Does taking metformin with food make it work better?
Is glyburide similar to metformin?
Which is safer metformin or glyburide?
Is glyburide stronger than metformin?
Which is safer glyburide or glipizide?
Is there a better drug than metformin for diabetes?
What is the black box warning for glyburide?
What is the generic name for glucovance?
Does glyburide raise or lower blood sugar?
Does glyburide work immediately?
Is glyburide still on the market?
Is it safe to take glyburide and metformin?
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