EplerenonePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Eplerenone
    Generic for Inspra
    30 tablets $10.8 USD
    Save $109.50
  3. Eplerenone
    Generic for Inspra
    30 tablets $11.1 USD
    Save $109.20
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Save up to 90% of your branded or generic medications using the Now Patient Rx Advantage Card

Do you need a prescription for eplerenone?

Yes, eplerenone is only available with a valid physician Rx.

How much is eplerenone without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase eplerenone, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for eplerenone in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a eplerenone savings card?

Yes. Save up to 90% on your eplerenone with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a eplerenone coupon provider in the US?

No. Now Patient does not provide eplerenone coupons or FREE eplerenone samples.

Do you accept commercial, Medicare or Medicaid coverage for eplerenone in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much eplerenone?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using eplerenone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much eplerenone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic eplerenone?

US brand name of eplerenone and manufacturer

Eplerenone is available under the brand name Inspra, which is manufactured by Pfizer, Inc.

UK brand name of eplerenone and manufacturer

In the UK, eplerenone is available under the brand name Inspra, which is manufactured by Pfizer

Availability of eplerenone

Eplerenone is available by prescription only.

FDA approval of eplerenone

Eplerenone has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of hypertension (high blood pressure) and for improving survival in patients with heart failure after a heart attack.

NHS prescription (UK) for eplerenone

Eplerenone is available in the UK with an NHS prescription.

Mechanism of action

Eplerenone is a selective aldosterone receptor antagonist (blocker). It works by blocking the effects of aldosterone, a hormone that can increase salt and fluid retention in the body. By blocking aldosterone, eplerenone helps to reduce fluid buildup and lower blood pressure.

Uses of eplerenone

Eplerenone is an antihypertensive primarily used for the following conditions:

  • Hypertension (high blood pressure)
  • Congestive heart failure after a heart attack

Dosage of eplerenone

The dose of eplerenone may vary depending on the individual patient and the condition being treated. It is important to follow the instructions provided by your healthcare provider.

Is it safe to take eplerenone if I am pregnant or planning on becoming pregnant?

Eplerenone is not recommended during pregnancy, as it may cause harm to the developing fetus. If you are pregnant or planning to become pregnant, it is important to discuss the potential risks and benefits of using eplerenone with your healthcare provider. They can help determine the best course of action for your specific situation.

Is it safe with breastfeeding?

It is not recommended to use eplerenone while breastfeeding, as it may pass into breast milk and potentially cause harm to the nursing infant. Consult with your healthcare provider for suitable alternatives or considerations.

Precautions and warnings for eplerenone

  • Tell your doctor if  you have high potassium blood levels (hyperkalemia), kidney disease, or diabetes before starting this medication
  • Avoid grapefruit and grapefruit juice while taking eplerenone

Side effects of eplerenone

In clinical trials common side effects of eplerenone may include:

  • Dizziness
  • Fatigue
  • Diarrhea
  • Elevated potassium levels
  • Increased blood sugar levels
  • Hyperkalemia with renal dysfunction
  • Irregular heartbeat

Get medical advice right away if you have a serious side effects such as an allergic reaction. Symptoms include hives, trouble breathing, worsening shortness of breath, sore throat, chest pain, swelling of the face, tongue or throat, skin rash, blisters, and serious skin reactions.

Interactions with other drugs

Eplerenone may interact with certain medications, including amiloride, itraconazole, fluconazole, ketoconazole, spironolactone, triamterene, angiotensin converting enzyme (ACE) inhibitors such as enalapril, angiotensin II receptor antagonists such as losartan, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen, potassium-sparing diuretics, potassium supplements, clarithromycin, erythromycin, ritonavir, saquinavir, lithium, nefazodone, and verapamil. It is important to inform your healthcare professional about all the prescription drugs, over the counter nonprescription medications, salt substitutes, herbal products, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.


  • FDA Prescribing Information for Eplerenone
  • NHS – Eplerenone
  • WebMD – Eplerenone
  • Drugs.com – Eplerenone


Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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