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MEDICAL INFORMATION
Deuruxolitinib Key Facts
What dosages is Deuruxolitinib available in?
Deuruxolitinib is available as one strength and formulation:
8 mg oral tablet — taken twice daily (BID), with or without food
There is only one approved dose; the 12 mg strength was evaluated in clinical trials but is not approved by the FDA.
What is Deuruxolitinib used for?
Deuruxolitinib is indicated for the treatment of adults with severe alopecia areata (AA). Alopecia areata is an autoimmune condition in which the immune system mistakenly attacks hair follicles, causing partial or complete hair loss on the scalp and body. Severe alopecia areata is defined as 50% or more scalp hair loss.
Deuruxolitinib was FDA-approved on July 25, 2024, and commercially launched in the United States in July 2025. The safety and effectiveness of Deuruxolitinib have not been established in pediatric patients.
How does Deuruxolitinib work?
Deuruxolitinib is a selective oral Janus kinase (JAK) inhibitor that targets the JAK1 and JAK2 pathways. In alopecia areata, the immune system becomes overactive and attacks hair follicles, disrupting the normal hair growth cycle.
JAK enzymes are proteins that transmit signals responsible for immune activation and inflammation. By binding to and inhibiting JAK1 and JAK2, Deuruxolitinib blocks this overactive immune response, reducing inflammation of the hair follicle and allowing hair to regrow. This treats the condition at its source rather than simply addressing symptoms on the surface.
How do I take Deuruxolitinib?
The recommended dose of Deuruxolitinib is 8 mg taken orally twice daily, with or without food. If a dose is missed, skip that dose and resume at the next scheduled time — do not take two doses at once.
Before starting Deuruxolitinib, your doctor must carry out the following pre-treatment assessments:
CYP2C9 genotype testing — to confirm you are not a poor metabolizer of this enzyme (see safety section)
Check for use of moderate or strong CYP2C9 inhibitors — Deuruxolitinib is contraindicated with these drugs
Complete blood count (CBC) — treatment is not recommended if absolute lymphocyte count is below 500 cells/mm³, absolute neutrophil count below 1,000 cells/mm³, or hemoglobin below 8 g/dL
Tuberculosis (TB) screening — active TB must be treated before starting Deuruxolitinib
Vaccinations — complete any required immunisations, including for herpes zoster, before starting treatment
Deuruxolitinib is dispensed through specialty pharmacy. Your doctor’s office will coordinate access through the Deuruxolitinib Support programme.
Is it safe for me to take Deuruxolitinib?
Deuruxolitinib carries an FDA Boxed Warning — the most serious type of safety warning. It is important to discuss all risks and benefits with your doctor before starting treatment.
Deuruxolitinib should not be used if you:
Are a CYP2C9 poor metabolizer (a genetic variant affecting how your body processes the drug)
Are currently taking moderate or strong CYP2C9 inhibitors
Have an active, untreated infection
Have severely impaired kidney function (eGFR < 30 mL/min) — not recommended
Use with caution and discuss with your doctor if you:
Are aged 50 or over with one or more cardiovascular risk factors (high blood pressure, high cholesterol, diabetes)
Have a history of blood clots, heart disease, or stroke
Are immunocompromised, have diabetes, or chronic lung disease
Are pregnant, planning to become pregnant, or breastfeeding — Deuruxolitinib may cause fetal harm
Deuruxolitinib Common Side Effects
The most common side effects of Deuruxolitinib (occurring in 1% or more of patients in clinical trials) include:
Headache (12.4%)
Acne or acneiform dermatitis (10%)
Nasopharyngitis — congestion, sore throat, or cold-like symptoms (8.1%)
Elevated blood creatine phosphokinase (CPK) — a muscle enzyme marker (5.3%)
Hyperlipidaemia — increased cholesterol and/or triglycerides
Fatigue, tiredness, or drowsiness
Weight gain
Lymphopenia — low white blood cell count
Thrombocytosis — elevated platelet count
Anaemia — low red blood cell count
Skin and soft tissue infections (e.g. folliculitis, impetigo)
Neutropenia — low neutrophil count
Herpes virus reactivation (including shingles/herpes zoster)
Your doctor will monitor you with regular blood tests before and during treatment to check lipid levels, blood cell counts, and other parameters.
Deuruxolitinib Serious Side Effects
Deuruxolitinib carries a Boxed Warning for the following serious risks. Contact your healthcare provider immediately — or seek emergency help — if you experience any of the following:
Serious infections: Deuruxolitinib suppresses your immune system. Bacterial, fungal, and viral infections — including TB, fungal infections, and opportunistic infections — have occurred and can be life-threatening
Cardiovascular events: increased risk of heart attack, stroke, and cardiovascular death, particularly in those aged 50+ with existing heart disease risk factors
Blood clots (thrombosis): including deep vein thrombosis (DVT), pulmonary embolism (PE), and cerebral venous sinus thrombosis (CVST). Seek emergency care immediately if you experience chest pain, sudden shortness of breath, leg swelling, or sudden severe headache
Malignancies (cancers): including lymphoma and other cancers have been observed with JAK inhibitor therapy. Risk may be higher in current or past smokers
Gastrointestinal perforations: tears in the stomach or intestines — seek emergency care if you have severe stomach pain or changes in bowel habits
Increased risk of mortality: JAK inhibitors have been associated with increased risk of death in patients aged 50+ with at least one heart disease risk factor
Laboratory abnormalities: changes in blood counts, lipid levels, and creatine phosphokinase levels require monitoring
Effects of other drugs, drug classes and over-the-counter products on Deuruxolitinib
Several important drug interactions apply to Deuruxolitinib:
Moderate or strong CYP2C9 inhibitors: Deuruxolitinib is contraindicated with these. Always inform your doctor and pharmacist of all medications you take
Other JAK inhibitors: Deuruxolitinib should not be combined with other JAK inhibitors
Biologic immunomodulators: concomitant use is not recommended
Cyclosporine or other potent immunosuppressants: use alongside Deuruxolitinib is not recommended
Live vaccines: do not receive any live vaccines immediately before or during Deuruxolitinib treatment
A unique requirement for Deuruxolitinib is CYP2C9 genetic testing before starting. Sun Pharma covers the cost of this genotyping test through LabCorp or Quest as part of the Deuruxolitinib Support programme.
Always inform your doctor and pharmacist of all medications, supplements, vitamins, and herbal products you are taking before starting Deuruxolitinib.
Who makes Deuruxolitinib?
Various FDA-approved generic manufacturers
Is Deuruxolitinib safe in pregnancy?
No. Deuruxolitinib may cause fetal harm and should not be used during pregnancy. Based on animal studies, Deuruxolitinib has been associated with reduced fetal weight, skeletal malformations, decreased pup survival, and adverse effects on reproductive outcomes in offspring.
Women of reproductive potential should use effective contraception during treatment and for a recommended period after stopping. Patients who become pregnant while taking Deuruxolitinib should notify their healthcare provider immediately. Pregnancy exposures should be reported to Sun Pharmaceutical Industries, Inc. at 1-800-818-4555.
It is not known whether Deuruxolitinib passes into human breast milk. Given the potential for harm to a breastfed infant, breastfeeding is not recommended during treatment.
What is the brand name for Deuruxolitinib?
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
HOW IT WORKS
Order Delivery Guide


How will my order be delivered?
All orders are shipped in discreet and unmarked packaging, making them suitable for delivery to your home, workplace, or a neighbour. For your protection and safety, your first order can only be delivered to the address that is registered with NowPatient. Future orders can be delivered to any address you choose.
Where does NowPatient deliver?
NowPatient delivers to the UK, Europe, and worldwide. NHS services (such as NHS Online Pharmacy and NHS Pharmacy First) are available to patients in England only. Our private services and online pharmacy are available across the UK, with international shipping available to European and worldwide addresses. Please note that some remote or rural postcodes may experience slightly longer delivery times, and tracking availability for worldwide orders may vary depending on the destination country.
What delivery options are available?
UK orders are shipped via Royal Mail Tracked 24 & Signed, with next-day delivery as standard. European deliveries are sent via Royal Mail Tracked and typically arrive within 3–5 working days. Worldwide deliveries take 7–21 working days and are tracked where available in the destination country.
Delivery charges apply for most services. Shipping is included in the price for patients using our Get Treated Privately service in England, and is free for NHS Quit Smoking Service orders.
When will my order be dispatched?
We aim to dispatch all orders placed Monday to Friday before 3:00pm on the same working day. Orders placed after 3:00pm, or over weekends and bank holidays, will be dispatched on the next available working day.
Do you offer next-day delivery?
Yes. All UK orders are shipped via Royal Mail Tracked 24 & Signed, which delivers next day as standard. To qualify for same-day dispatch, please place your order before 3:00pm Monday to Friday. Orders placed after this time, or over weekends and bank holidays, will be dispatched on the next available working day.
Do you deliver temperature-sensitive or cold-chain medications?
Yes. We use a specialist courier service for all thermo-sensitive deliveries (such as insulin, GLP-1 weight loss injections like Mounjaro, and other refrigerated medications). Cold chain-validated packaging is used throughout the entire delivery process to ensure product quality, safety, and efficacy are always maintained.
How is cold-chain packaging handled?
Temperature-sensitive products are packed using validated cold chain packaging that maintains the required storage temperature throughout transit. Your parcel will normally receive an estimated delivery window from the courier on the day of delivery, so you can ensure someone is available to receive it. If you have concerns about receiving a cold-chain delivery, please contact our customer care team in advance.
Do you deliver controlled drugs?
Yes. Controlled drugs are delivered using a specialist courier service to ensure secure and compliant handling in accordance with UK regulations. These deliveries will always require a signature upon receipt.
How do I track my order?
Once your order has been dispatched, you will receive a dispatch notification containing your tracking details. You can also view your tracking information at any time in the 'Notification Feed' section on your account dashboard. Tracking is available for all delivery options.
Will I receive status updates about my order?
Yes. NowPatient uses a structured notification system to keep you fully informed throughout the order process. Every time your order status changes — from approval through to dispatch and delivery — you will be notified immediately. Notifications are sent via email and appear in the 'Notifications' section of your account homepage (accessible via the bell icon). This includes updates when your treatment is approved, dispensed, and shipped.
What order statuses will I see?
You can expect to see the following key status updates: Order Received, Prescription Approved (where applicable), Order Dispensed, Dispatched (with tracking reference), and Delivered.
Can I change my delivery address?
For your first order, delivery must be made to the address registered with NowPatient at the time of sign-up. This is a safety measure to verify your identity and protect your account. From your second order onwards, you can select from any saved address in your account or add a new delivery address during checkout.
Can I have my order delivered to my workplace or a neighbour?
Yes. From your second order onwards, you can have your medication delivered to any address, including your workplace, a family member's address, or a neighbour. All parcels are sent in discreet, unmarked packaging, so the contents will not be identifiable.
How do I update or add a new delivery address?
You can manage your delivery addresses directly within your NowPatient account settings. Additional addresses can also be added during the checkout process when selecting your delivery address. Simply select 'Add a new address' and enter the required details.
What should I do if my order hasn't arrived?
If you have not received your order within the expected delivery window, please first check your tracking details in the 'Notification Feed' section of your account dashboard. If after 10 days of dispatch you have still not received your delivery, please contact our customer care team and we will work to resolve the issue as quickly as possible.
What if my order arrives damaged?
If your order arrives in a damaged condition, please do not use the medication and contact our customer care team immediately. Please retain the original packaging and, if possible, take photographs of the damage, as this will help us raise a claim with the courier and arrange a replacement for you as quickly as possible.
My tracking shows delivered but I haven't received my parcel — what should I do?
First, check with any neighbours or safe locations at your property (such as a porch or outbuilding). If you still cannot locate your parcel, please contact our customer care team and we will investigate the matter with the courier on your behalf.
What happens if I miss my delivery?
If you miss a delivery, the courier will typically leave a card with instructions for rescheduling or collecting your parcel from a local depot. For cold-chain deliveries, it is particularly important to arrange redelivery promptly to maintain product integrity. If you have concerns about a missed cold-chain delivery, please contact our customer care team for guidance.
If you ship international, do I need to handle duties?
No. Our prices include customs duties, wherever you are located.
How are NHS repeat prescriptions delivered?
Once your GP has approved your prescription request, NowPatient's regulated online pharmacy will dispense and dispatch your medication. You will be notified at each stage of the process. NHS prescriptions are dispatched via Royal Mail Tracked 24 & Signed for next-day delivery, provided the order is placed before 3:00pm on a
working day.
Is delivery free for NHS prescriptions?
No. There is a small cost applied to all NHS prescription deliveries. This allows us to keep our service operational. NHS Quit Smoking Service orders qualify for free delivery. If you are using the Get Treated Privately service in England, shipping is included within the consultation and treatment price.
Can I specify a preferred delivery date for my NHS prescription?
At this time, NowPatient dispatches orders on the same working day if placed before 3:00pm Monday to Friday. All UK NHS prescriptions are sent via Royal Mail Tracked 24 & Signed for next-day delivery, so you can plan accordingly once you receive your dispatch notification.
How are private prescription medications delivered after a telehealth consultation?
Following your telehealth or video consultation, if a treatment is prescribed, it will be added to your cart automatically. After you complete checkout and payment, your order is sent to NowPatient's regulated online pharmacy for processing. You will receive status updates at every stage and your medication will be dispatched in discreet, unmarked packaging.
How quickly will I receive medication after my consultation?
If your consultation and checkout are completed before 3:00pm on a working day, we aim to dispatch your medication the same day. The total time to delivery will depend on the delivery method you select at checkout.
Is the packaging discreet?
Yes. All NowPatient orders are shipped in plain, unmarked packaging with no branding or indication of the contents on the outside. The packaging is suitable for delivery to your home, workplace, or a neighbour.
Will my parcel require a signature?
Yes. All UK orders are sent via Royal Mail Tracked 24 & Signed, which requires a signature upon delivery. Controlled drug deliveries will always require a signature regardless of the shipping method. For cold-chain deliveries, a signature is required to ensure someone is available to receive the medication promptly and maintain product integrity. For European and worldwide orders, signature requirements may vary depending on the destination country and the service available.
How do I contact NowPatient about a delivery issue?
You can reach our customer care team through the NowPatient website or app. Go to your account and use the Help or Contact Us section to raise a query. Our team is available to assist with any delivery-related concerns including missing parcels, tracking queries, or delivery address changes.
What are NowPatient's customer care hours?
Please visit the Contact Us section of the NowPatient website or app for up-to-date information on our customer care operating hours and available contact methods.
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