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Coagulation Factor Xa is is available in single-use vials of 200 mg of Coagulation Factor Xa (recombinant), inactivated-zhzo.

Coagulation Factor Xa is a recombinant modified human factor Xa (FXa) protein used to reverse the blood-thinning effect of apixaban or rivaroxaban in emergency situations.

Coagulation Factor Xa works by acting as a decoy to bind and neutralize the anticoagulant effects of factor Xa inhibitors like rivaroxaban and apixaban. By binding to the inhibitors, Coagulation Factor Xa frees up your body’s own factor Xa, which can then generate thrombin and help restore normal hemostasis during bleeding emergencies.

The dose of Coagulation Factor Xa is based on the specific FXa inhibitor, dose of FXa inhibitor, and time since the your last dose. It is given as a 400 mg or 800 mg IV bolus at a rate of 30 mg/min followed by continuous infusion 4 mg to 8 mg/min for 120 minutes.

Coagulation Factor Xa is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Coagulation Factor Xa:

• Urinary tract infections (UTIs)
• Pneumonia

Serious side effects are rare with Coagulation Factor Xa. Contact your healthcare provider immediately if you experience any of the following:

• Arterial and venous thromboembolic events (blood clots), which can lead to stroke, myocardial infarction (heart attack), pulmonary embolism (blood clot in the lungs), deep vein thrombosis (blood clot in a deep vein), cardiac arrest, and sudden death.

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

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