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Coagulation Factor IX (Recombinant) is available as a lyophilized powder in single-use vials containing nominally 250, 500, 1000, 2000, or 3000 IU.

Coagulation Factor IX (Recombinant) is a coagulation factor replacement and is used to prevent or treat bleeding in adults and children with hemophilia B.

Coagulation Factor IX (Recombinant) is a clotting factor replacement used for people who are missing the clotting factor called factor IX. Factor IX is one of many proteins known as clotting factors that works in your body to form blood clots. Factor IX recombinant replaces the missing factor IX to help prevent and treat bleeding in people with hemophilia B.

Coagulation Factor IX (Recombinant) is given as an injection into the veins (intravenous or IV).

• Routine prevention of bleeds: Your provider will calculate your dose based on things like age, body weight, and response to the medication. The dose is typically given through your veins (IV), and how often you receive it will depend on the brand
• Coagulation Factor IX (Recombinant): The typical dose is 100 international units (IU)/kg of body weight given IV once weekly
• Alprolix: The typical starting dose is 50 IU/kg to 60 IU/kg given IV once weekly, or 100 IU/kg once every 10 days
• Ixinity: The typical dose is 40 IU/kg to 70 IU/kg IV twice weekly
• Rebinyn: The typical dose is 40 IU/kg IV once weekly

On-demand treatment of bleeding, including during surgery: Your provider will calculate your dose based on things like body weight, how serious your bleed is, where the bleed is, the desired level of factor IX in your body, and the brand of factor IX recombinant you’re receiving.

Coagulation Factor IX (Recombinant) is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Do not use in patients who have manifested life-threatening, immediate hypersensitivity reactions, including anaphylaxis, to the product or its components, including hamster protein.

Common side effects of Coagulation Factor IX (Recombinant):

• Headache
• Dizziness
• Injection site reaction
• Nausea
• Pain at injection site
• Rash
• Changes in taste

Serious side effects are rare with Coagulation Factor IX (Recombinant). Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reaction (anaphylaxis): difficulty breathing, hives, itching, fast heartbeat, tightness in the throat, nausea, stomach pain, dizziness, lightheadedness, swelling in the face or tongue
  Blood clots: lungs (cough, difficulty breathing, chest pain), legs (redness, pain, tenderness, swelling of the skin), heart attack (chest pain, pain in the arms or shoulders, pain in the neck or jaw), stroke (difficulty speaking, numbness on one side of the body, confusion)

There are no major drug interactions listed for Coagulation Factor IX (Recombinant). However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

It is not known if Coagulation Factor IX (Recombinant) can harm your unborn baby. Coagulation Factor IX (Recombinant) should only be used during pregnancy if the benefit to you is worth the possible risk to your baby.

• Alprolix
• Benefix