BENEFIX
NowPatient helps you obtain your BENEFIX prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by Pfizer
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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BENEFIX key facts
What is BENEFIX?
BeneFIX is the brand name for recombinant coagulation factor IX and is available as an IV injection.
What dosages is BENEFIX available in?
BeneFIX is available as a lyophilized powder in single-use vials containing nominally 250, 500, 1000, 2000, or 3000 IU.
What is BENEFIX used for?
BeneFIX is a coagulation factor replacement and is used to prevent or treat bleeding in adults and children with hemophilia B.
How does BENEFIX work?
BeneFIX is a clotting factor replacement used for people who are missing the clotting factor called factor IX. Factor IX is one of many proteins known as clotting factors that works in your body to form blood clots. Factor IX recombinant replaces the missing factor IX to help prevent and treat bleeding in people with hemophilia B.
How do I take BENEFIX?
BeneFIX is given as an injection into the veins (intravenous or IV).
- Routine prevention of bleeds: Your provider will calculate your dose based on things like age, body weight, and response to the medication. The dose is typically given through your veins (IV), and how often you receive it will depend on the brand
- BeneFix: The typical dose is 100 international units (IU)/kg of body weight given IV once weekly
- Alprolix: The typical starting dose is 50 IU/kg to 60 IU/kg given IV once weekly, or 100 IU/kg once every 10 days
- Ixinity: The typical dose is 40 IU/kg to 70 IU/kg IV twice weekly
- Rebinyn: The typical dose is 40 IU/kg IV once weekly
On-demand treatment of bleeding, including during surgery: Your provider will calculate your dose based on things like body weight, how serious your bleed is, where the bleed is, the desired level of factor IX in your body, and the brand of factor IX recombinant you’re receiving.
Is it safe for me to take BENEFIX?
BeneFIX is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Do not use in patients who have manifested life-threatening, immediate hypersensitivity reactions, including anaphylaxis, to the product or its components, including hamster protein.
BENEFIX Common Side Effects
Common side effects of BeneFIX:
- Headache
- Dizziness
- Injection site reaction
- Nausea
- Pain at injection site
- Rash
- Changes in taste
BENEFIX Serious Side Effects
Serious side effects are rare with BeneFIX. Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction (anaphylaxis): difficulty breathing, hives, itching, fast heartbeat, tightness in the throat, nausea, stomach pain, dizziness, lightheadedness, swelling in the face or tongue
Blood clots: lungs (cough, difficulty breathing, chest pain), legs (redness, pain, tenderness, swelling of the skin), heart attack (chest pain, pain in the arms or shoulders, pain in the neck or jaw), stroke (difficulty speaking, numbness on one side of the body, confusion)
Effects of other drugs, drug classes and over-the-counter products on BENEFIX
There are no major drug interactions listed for BeneFIX. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Who makes BENEFIX?
Pfizer
Is BENEFIX safe in pregnancy?
It is not known if BeneFIX can harm your unborn baby. BeneFIX should only be used during pregnancy if the benefit to you is worth the possible risk to your baby.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my BENEFIX prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your BENEFIX prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient BENEFIX savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient BENEFIX savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for BENEFIX | Canadian Prescription Savings* for BENEFIX | BENEFIX Drug Coupon* | BENEFIX Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of BENEFIX?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for BENEFIX | Canadian Prescription Savings* for BENEFIX | BENEFIX Drug Coupon* | BENEFIX Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the BENEFIX savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the BENEFIX drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for BENEFIX, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the BENEFIX prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, BENEFIX is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed BENEFIX for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the BENEFIX prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the BENEFIX prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for BENEFIX
If you are having trouble paying for your BENEFIX medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for BENEFIX you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- BENEFIX is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers BENEFIX
- If BENEFIX is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for BENEFIX
If you are having trouble paying for your BENEFIX medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for BENEFIX you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers BENEFIX
- If BENEFIX is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for BENEFIX
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your BENEFIX treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for BENEFIX you will need to meet the following criteria:
- You must be currently insured and have coverage for BENEFIX
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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