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Bosutinib is available as a 100 mg, 400 mg, and 500 mg oral tablet and a 50 mg and 100 mg oral capsule.

Bosutinib is a BCR-ABL tyrosine kinase inhibitor and is used to treat Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML).

Bosutinib is a tyrosine kinase inhibitor (TKI). It blocks a certain protein in your body called BCR-ABL tyrosine kinase. This protein is only found on cancer cells like those of CML and typically causes the cancer cells to grow and multiply. By blocking BCR-ABL from working, Bosutinib stops the cancer from growing and spreading.

Bosutinib is typically dosed as follows:
Adults

• Newly diagnosed with Ph+ CML: The typical dose is 400 mg by mouth once daily
• Previously treated with a similar medication: The typical dose of Bosutinib is 500 mg by mouth once daily

Children aged 1 year and older

• The dose is based on your child’s body surface area or body size, which takes into account weight and height
• Newly diagnosed with Ph+ CML: The typical dose ranges from 150 mg to 400 mg by mouth once daily, depending on your child’s body size
• Previously treated with a similar medication: The typical dose of Bosutinib ranges from 200 mg to 500 mg by mouth once daily, depending on your child’s body size

Your dose might differ if you have kidney or liver problems. Your provider will also adjust your dose if you have bothersome or severe side effects.

Bosutinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Bosutinib:

• High creatinine levels in blood
• Diarrhea
• Low blood cell counts
• High liver enzyme levels in blood
• Nausea
• Rash
• Stomach pain
• Vomiting
• Fatigue
• Respiratory tract infection
• Fever
• Headache

Serious side effects are rare with Bosutinib. Contact your healthcare provider immediately if you experience any of the following.

• Infections: repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
• Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, throwing up blood, blood in the urine, bloody or black and tarry stool
  Liver damage: dark urine, right-sided stomach pain, yellowing of the eyes or skin, tiredness, loss of appetite, nausea, vomiting
• Heart problems: chest pain, racing heartbeat, shortness of breath that usually worsens with activity or while lying flat, swelling of your legs or feet, sudden weight gain, fatigue, dizziness

The following medications may interact with Bosutinib:

• Strong and Moderate CYP3A Inhibitors: Avoid concomitant use with Bosutinib
• Strong CYP3A Inducers: Avoid concomitant use with Bosutinib
• Proton Pump Inhibitors: Use short-acting antacids or H2 blockers as an alternative to proton pump inhibitors

Various FDA-approved generic manufacturers

Bosutinib can harm your unborn baby. Females who are able to become pregnant should have a pregnancy test before starting treatment with Bosutinib. Tell your doctor right away if you become pregnant during treatment with Bosutinib.
Females who are able to become pregnant should use effective birth control (contraception) during treatment with Bosutinib and for 2 weeks after the last dose. Talk to your doctor about birth control methods that may be right for you.

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