Used for Cancer

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Updated on 24 Apr 2024

Learn more about bosutinib

What dosages is bosutinib available in?

What dosages is bosutinib available in?

bosutinib is available as a 100 mg, 400 mg, and 500 mg oral tablet and a 50 mg and 100 mg oral capsule.

What is bosutinib used for?

What is bosutinib used for?

bosutinib is a BCR-ABL tyrosine kinase inhibitor and is used to treat Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML).

How does bosutinib work?

How does bosutinib work?

bosutinib is a tyrosine kinase inhibitor (TKI). It blocks a certain protein in your body called BCR-ABL tyrosine kinase. This protein is only found on cancer cells like those of CML and typically causes the cancer cells to grow and multiply. By blocking BCR-ABL from working, bosutinib stops the cancer from growing and spreading.

How do I take bosutinib?

How do I take bosutinib?

bosutinib is typically dosed as follows:

  • Newly diagnosed with Ph+ CML: The typical dose is 400 mg by mouth once daily
  • Previously treated with a similar medication: The typical dose of bosutinib (bosutinib) is 500 mg by mouth once daily

Children aged 1 year and older

  • The dose is based on your child’s body surface area or body size, which takes into account weight and height
  • Newly diagnosed with Ph+ CML: The typical dose ranges from 150 mg to 400 mg by mouth once daily, depending on your child’s body size
  • Previously treated with a similar medication: The typical dose of bosutinib (bosutinib) ranges from 200 mg to 500 mg by mouth once daily, depending on your child’s body size

Your dose might differ if you have kidney or liver problems. Your provider will also adjust your dose if you have bothersome or severe side effects.

Is it safe for me to take bosutinib?

Is it safe for me to take bosutinib?

bosutinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

bosutinib Common Side Effects

bosutinib Common Side Effects

Common side effects of bosutinib:

  • High creatinine levels in blood
  • Diarrhea
  • Low blood cell counts
  • High liver enzyme levels in blood
  • Nausea
  • Rash
  • Stomach pain
  • Vomiting
  • Fatigue
  • Respiratory tract infection
  • Fever
  • Headache
bosutinib Serious Side Effects

bosutinib Serious Side Effects

Serious side effects are rare with bosutinib. Contact your healthcare provider immediately if you experience any of the following.

  • Infections: repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
  • Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, throwing up blood, blood in the urine, bloody or black and tarry stool
    Liver damage: dark urine, right-sided stomach pain, yellowing of the eyes or skin, tiredness, loss of appetite, nausea, vomiting
  • Heart problems: chest pain, racing heartbeat, shortness of breath that usually worsens with activity or while lying flat, swelling of your legs or feet, sudden weight gain, fatigue, dizziness
Effects of other drugs, drug classes and over-the-counter products on bosutinib

Effects of other drugs, drug classes and over-the-counter products on bosutinib

The following medications may interact with bosutinib:

  • Strong and Moderate CYP3A Inhibitors: Avoid concomitant use with bosutinib
  • Strong CYP3A Inducers: Avoid concomitant use with bosutinib
  • Proton Pump Inhibitors: Use short-acting antacids or H2 blockers as an alternative to proton pump inhibitors
Who makes bosutinib?

Who makes bosutinib?

Various FDA-approved generic manufacturers

Is bosutinib safe in pregnancy?

Is bosutinib safe in pregnancy?

bosutinib can harm your unborn baby. Females who are able to become pregnant should have a pregnancy test before starting treatment with bosutinib. Tell your doctor right away if you become pregnant during treatment with bosutinib.
Females who are able to become pregnant should use effective birth control (contraception) during treatment with bosutinib and for 2 weeks after the last dose. Talk to your doctor about birth control methods that may be right for you.


What to do if you missed your bosutinib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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