BOSULIF
Used for Cancer
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Manufactured by Pfizer
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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BOSULIF Uses, Side Effects, Interactions, Warnings & Dosing
What is BOSULIF?
BOSULIF is the brand name for bosutinib and is available as an oral capsule and tablet.
What dosages is BOSULIF available in?
BOSULIF is available as a 100 mg, 400 mg, and 500 mg oral tablet and a 50 mg and 100 mg oral capsule.
What is BOSULIF used for?
BOSULIF is a BCR-ABL tyrosine kinase inhibitor and is used to treat Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML).
How does BOSULIF work?
BOSULIF is a tyrosine kinase inhibitor (TKI). It blocks a certain protein in your body called BCR-ABL tyrosine kinase. This protein is only found on cancer cells like those of CML and typically causes the cancer cells to grow and multiply. By blocking BCR-ABL from working, BOSULIF stops the cancer from growing and spreading.
How do I take BOSULIF?
BOSULIF is typically dosed as follows:
Adults
- Newly diagnosed with Ph+ CML: The typical dose is 400 mg by mouth once daily
- Previously treated with a similar medication: The typical dose of Bosulif (bosutinib) is 500 mg by mouth once daily
Children aged 1 year and older
- The dose is based on your child’s body surface area or body size, which takes into account weight and height
- Newly diagnosed with Ph+ CML: The typical dose ranges from 150 mg to 400 mg by mouth once daily, depending on your child’s body size
- Previously treated with a similar medication: The typical dose of Bosulif (bosutinib) ranges from 200 mg to 500 mg by mouth once daily, depending on your child’s body size
Your dose might differ if you have kidney or liver problems. Your provider will also adjust your dose if you have bothersome or severe side effects.
Is it safe for me to take BOSULIF?
BOSULIF is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
BOSULIF Common Side Effects
Common side effects of BOSULIF:
- High creatinine levels in blood
- Diarrhea
- Low blood cell counts
- High liver enzyme levels in blood
- Nausea
- Rash
- Stomach pain
- Vomiting
- Fatigue
- Respiratory tract infection
- Fever
- Headache
BOSULIF Serious Side Effects
Serious side effects are rare with BOSULIF. Contact your healthcare provider immediately if you experience any of the following.
- Infections: repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
- Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, throwing up blood, blood in the urine, bloody or black and tarry stool
Liver damage: dark urine, right-sided stomach pain, yellowing of the eyes or skin, tiredness, loss of appetite, nausea, vomiting - Heart problems: chest pain, racing heartbeat, shortness of breath that usually worsens with activity or while lying flat, swelling of your legs or feet, sudden weight gain, fatigue, dizziness
Effects of other drugs, drug classes and over-the-counter products on BOSULIF
The following medications may interact with BOSULIF:
- Strong and Moderate CYP3A Inhibitors: Avoid concomitant use with BOSULIF
- Strong CYP3A Inducers: Avoid concomitant use with BOSULIF
- Proton Pump Inhibitors: Use short-acting antacids or H2 blockers as an alternative to proton pump inhibitors
Who makes BOSULIF?
Pfizer
Is BOSULIF safe in pregnancy?
BOSULIF can harm your unborn baby. Females who are able to become pregnant should have a pregnancy test before starting treatment with BOSULIF. Tell your doctor right away if you become pregnant during treatment with BOSULIF.
Females who are able to become pregnant should use effective birth control (contraception) during treatment with BOSULIF and for 2 weeks after the last dose. Talk to your doctor about birth control methods that may be right for you.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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