Used for Cancer

View BOSULIF savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or BOSULIF Patient Assistance Program.

Programs are suitable for individuals who want to buy BOSULIF without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Pfizer

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about BOSULIF

What is BOSULIF?

What is BOSULIF?

BOSULIF is the brand name for bosutinib and is available as an oral capsule and tablet.

What dosages is BOSULIF available in?

What dosages is BOSULIF available in?

BOSULIF is available as a 100 mg, 400 mg, and 500 mg oral tablet and a 50 mg and 100 mg oral capsule.

What is BOSULIF used for?

What is BOSULIF used for?

BOSULIF is a BCR-ABL tyrosine kinase inhibitor and is used to treat Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML).

How does BOSULIF work?

How does BOSULIF work?

BOSULIF is a tyrosine kinase inhibitor (TKI). It blocks a certain protein in your body called BCR-ABL tyrosine kinase. This protein is only found on cancer cells like those of CML and typically causes the cancer cells to grow and multiply. By blocking BCR-ABL from working, BOSULIF stops the cancer from growing and spreading.

How do I take BOSULIF?

How do I take BOSULIF?

BOSULIF is typically dosed as follows:

  • Newly diagnosed with Ph+ CML: The typical dose is 400 mg by mouth once daily
  • Previously treated with a similar medication: The typical dose of Bosulif (bosutinib) is 500 mg by mouth once daily

Children aged 1 year and older

  • The dose is based on your child’s body surface area or body size, which takes into account weight and height
  • Newly diagnosed with Ph+ CML: The typical dose ranges from 150 mg to 400 mg by mouth once daily, depending on your child’s body size
  • Previously treated with a similar medication: The typical dose of Bosulif (bosutinib) ranges from 200 mg to 500 mg by mouth once daily, depending on your child’s body size

Your dose might differ if you have kidney or liver problems. Your provider will also adjust your dose if you have bothersome or severe side effects.

Is it safe for me to take BOSULIF?

Is it safe for me to take BOSULIF?

BOSULIF is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

BOSULIF Common Side Effects

BOSULIF Common Side Effects

Common side effects of BOSULIF:

  • High creatinine levels in blood
  • Diarrhea
  • Low blood cell counts
  • High liver enzyme levels in blood
  • Nausea
  • Rash
  • Stomach pain
  • Vomiting
  • Fatigue
  • Respiratory tract infection
  • Fever
  • Headache
BOSULIF Serious Side Effects

BOSULIF Serious Side Effects

Serious side effects are rare with BOSULIF. Contact your healthcare provider immediately if you experience any of the following.

  • Infections: repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
  • Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, throwing up blood, blood in the urine, bloody or black and tarry stool
    Liver damage: dark urine, right-sided stomach pain, yellowing of the eyes or skin, tiredness, loss of appetite, nausea, vomiting
  • Heart problems: chest pain, racing heartbeat, shortness of breath that usually worsens with activity or while lying flat, swelling of your legs or feet, sudden weight gain, fatigue, dizziness
Effects of other drugs, drug classes and over-the-counter products on BOSULIF

Effects of other drugs, drug classes and over-the-counter products on BOSULIF

The following medications may interact with BOSULIF:

  • Strong and Moderate CYP3A Inhibitors: Avoid concomitant use with BOSULIF
  • Strong CYP3A Inducers: Avoid concomitant use with BOSULIF
  • Proton Pump Inhibitors: Use short-acting antacids or H2 blockers as an alternative to proton pump inhibitors
Who makes BOSULIF?

Who makes BOSULIF?


Is BOSULIF safe in pregnancy?

Is BOSULIF safe in pregnancy?

BOSULIF can harm your unborn baby. Females who are able to become pregnant should have a pregnancy test before starting treatment with BOSULIF. Tell your doctor right away if you become pregnant during treatment with BOSULIF.
Females who are able to become pregnant should use effective birth control (contraception) during treatment with BOSULIF and for 2 weeks after the last dose. Talk to your doctor about birth control methods that may be right for you.


What to do if you missed your BOSULIF dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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