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Atovaquone/Proguanil Hydrochloride is available as one of the following:

• Tablets (adult strength): 250 mg atovaquone and 100 mg proguanil hydrochloride
• Pediatric tablets: 62.5 mg atovaquone and 25 mg proguanil hydrochloride

Atovaquone/Proguanil Hydrochloride is an antimalarial and is used to prevent and treat malaria caused by plasmodium falciparum species.

Atovaquone/Proguanil Hydrochloride is a combination of two medications that work together to stop malaria from growing in your body. Atovaquone works by stopping the malaria parasite from being able to make energy for itself. Without energy, the malaria parasite dies off. Proguanil is thought to work by boosting atovaquone’s effect on the malaria parasite.

For malaria prevention: Typically, you’ll start Atovaquone/Proguanil Hydrochloride 1 to 2 days before you enter an area with malaria, and then continue taking the medication throughout your stay. After you leave from this area, you’ll need to take Atovaquone/Proguanil Hydrochloride for 7 more days. Atovaquone/Proguanil Hydrochloride should be taken with food or a milky drink.

Atovaquone/Proguanil Hydrochloride is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Known serious hypersensitivity reactions to atovaquone or proguanil hydrochloride or any component of the formulation
• Prophylaxis of P. falciparum malaria in patients with severe renal impairment (creatinine clearance <30 mL/min)

Common side effects of Atovaquone/Proguanil Hydrochloride:

• Stomach pain
• Nausea
• Vomiting
• Diarrhea
• Low appetite
• Headache
• Weakness
• Dizziness

Serious side effects are rare with Atovaquone/Proguanil Hydrochloride. Contact your healthcare provider immediately if you experience any of the following.

• Liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine

The following medications may interact with Atovaquone/Proguanil Hydrochloride:

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with Atovaquone/Proguanil Hydrochloride is not recommended
• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. Caution advised when initiating or withdrawing Atovaquone/Proguanil Hydrochloride in patients on anticoagulants; coagulation tests should be closely monitored
• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored

Various FDA-approved generic manufacturers

It is not known if Atovaquone/Proguanil Hydrochloride may harm your unborn baby. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Malarone