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Malarone is the brand name for atovaquone and proguanil hydrochloride and is available as an oral tablet and pediatric tablet.

Malarone is available as one of the following:

• Tablets (adult strength): 250 mg atovaquone and 100 mg proguanil hydrochloride
• Pediatric tablets: 62.5 mg atovaquone and 25 mg proguanil hydrochloride

Malarone is an antimalarial and is used to prevent and treat malaria caused by plasmodium falciparum species.

Malarone is a combination of two medications that work together to stop malaria from growing in your body. Atovaquone works by stopping the malaria parasite from being able to make energy for itself. Without energy, the malaria parasite dies off. Proguanil is thought to work by boosting atovaquone’s effect on the malaria parasite.

For malaria prevention: Typically, you’ll start Malarone 1 to 2 days before you enter an area with malaria, and then continue taking the medication throughout your stay. After you leave from this area, you’ll need to take Malarone for 7 more days. Malarone should be taken with food or a milky drink.

Malarone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Known serious hypersensitivity reactions to atovaquone or proguanil hydrochloride or any component of the formulation
• Prophylaxis of P. falciparum malaria in patients with severe renal impairment (creatinine clearance <30 mL/min)

Common side effects of Malarone:

• Stomach pain
• Nausea
• Vomiting
• Diarrhea
• Low appetite
• Headache
• Weakness
• Dizziness

Serious side effects are rare with Malarone. Contact your healthcare provider immediately if you experience any of the following.

• Liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine

The following medications may interact with Malarone:

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with Malarone is not recommended
• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. Caution advised when initiating or withdrawing Malarone in patients on anticoagulants; coagulation tests should be closely monitored
• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored

GlaxoSmithKline

It is not known if Malarone may harm your unborn baby. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Atovaquone/Proguanil Hydrochloride