AtovaquonePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Atovaquone
    Generic for Mepron
    210mL bottle of suspensions $109.51 USD
    Save $594.87
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Do you need a prescription for atovaquone?

Yes, atovaquone is only available with a valid physician Rx.

How much is atovaquone without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase atovaquone, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for atovaquone in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a atovaquone savings card?

Yes. Save up to 90% on your atovaquone with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a atovaquone coupon provider in the US?

No. Now Patient does not provide atovaquone coupons or FREE atovaquone samples.

Do you accept commercial, Medicare or Medicaid coverage for atovaquone in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much atovaquone?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using atovaquone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much atovaquone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

US brand name of atovaquone and manufacturer

Atovaquone is available in the US under the brand name Mepron. It is manufactured by GlaxoSmithKline.

UK brand name of atovaquone and manufacturer

Atovaquone is available in the UK under the brand name Wellvone. It is also manufactured by GlaxoSmithKline.

Prescription requirement for atovaquone

Atovaquone is a prescription medication in both the US and the UK. It is not available over the counter and requires a prescription from a healthcare provider.

FDA approval of atovaquone

Atovaquone has received FDA approval for the treatment and prevention of pneumocystis jirovecii pneumonia (PCP) in patients who are intolerant to trimethoprim-sulfamethoxazole, a common antibiotic used for PCP. It is also approved for the treatment and prevention of malaria.

Is atovaquone available in the UK on NHS?

Atovaquone is available on the NHS in the UK. It can be prescribed by healthcare providers for the treatment of specific medical conditions.

Mechanism of action

Atovaquone acts by inhibiting the mitochondrial electron transport chain of the plasmodium parasite, which is responsible for generating energy for its survival. Atovaquone specifically targets a protein called cytochrome bc1 complex, which is vital for the electron transport chain. By inhibiting this complex, atovaquone disrupts the parasite’s ability to generate adenosine triphosphate (ATP), which is necessary for its survival. This ultimately leads to the death of the parasite.

Uses of atovaquone

  • Atovaquone is an antimalarial medication for the treatment and prevention of malaria, particularly caused by plasmodium falciparum
  • Atovaquone is an alternative antimicrobial treatment for toxoplasmosis, a parasitic infection caused by the parasite toxoplasma gondii. It can effectively target and eliminate the parasites responsible for this condition
  • Atovaquone is used in managing pneumocystis carinii pneumonia (PCP) (also called Pneumocystis jiroveci) in patients who are intolerant to trimethoprim-sulfamethoxazole
  • Atovaquone is also sometimes used along with other medications to treat babesiosis (an infectious disease carried by ticks)

Dosage of atovaquone

The dosage of atovaquone will vary depending on the specific condition being treated, the severity of symptoms, and individual patient factors. It is important to follow the dosage instructions provided by your healthcare provider. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Precautions and warnings for atovaquone

  • Atovaquone should not be used in individuals who have a known allergy to the medication or any of its components
  • It is important to inform your healthcare provider about any existing medical conditions, including kidney or liver disease
  • If you are pregnant or breastfeeding, consult with a healthcare professional before taking  atovaquone, as its safety for these conditions has not been fully established
  • Atovaquone may interact with certain medications, including rifampin, rifabutin, and other drugs metabolized by the liver. It is important to inform your healthcare provider about all the prescription medications including over-the-counter drugs and supplements you are taking to avoid potential drug interactions
  • Atovaquone may cause gastrointestinal side effects, such as nausea, vomiting, and diarrhea

Side effects of atovaquone

Common side effects of atovaquone may include nausea, vomiting, diarrhea, headache, trouble sleeping and abdominal pain. It can also cause more serious side effects, such as liver dysfunction, allergic reactions, and blood disorders. It is important to seek medical attention if you experience any severe or persistent side effects.

Drug interactions

Atovaquone is mainly metabolized in the liver through the cytochrome P450 enzyme system, specifically the CYP3A4 enzyme. This enzyme plays a significant role in the metabolism of many drugs and can impact their pharmacokinetics. The metabolism of atovaquone can have several effects on its pharmacokinetics. One important aspect is the potential for drug interactions. Since atovaquone is primarily metabolized by CYP3A4, drugs that inhibit or induce this enzyme can affect its metabolism. Inhibitors of CYP3A4 can increase the concentration of atovaquone in the blood, leading to potential toxicity. On the other hand, inducers of CYP3A4 can decrease the concentration of atovaquone, reducing its effectiveness. Atovaquone may interact with certain medications, including rifampin, rifabutin, and other drugs that induce liver enzymes. It is important to inform your healthcare provider about all the medications you are taking to avoid potential interactions.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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