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Atovaquone is available as a 750 mg/5 ml oral suspension.

Atovaquone is an antiprotozoal that is used for the treatment and prevention of pneumonia caused by the Pneumocystis jirovecii fungus. This medication is used when people cannot tolerate the first-choice medication, trimethoprim-sulfamethoxazole.

Atovaquone is an antifungal medication. It prevents and treats the fungus, Pneumocystis jirovecii, from reproducing and causing pneumonia in your body.

Atovaquone is dosed as 1500 mg (10 mL) by mouth once daily with food for pneumonia prevention and 750 mg (5 mL) by mouth twice daily with food for 21 days for pneumonia treatment.

Atovaquone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known serious allergic/hypersensitivity reaction (e.g., angioedema, bronchospasm, throat tightness, urticaria) to Atovaquone or any of the components of Atovaquone.

Common side effects of Atovaquone:

• Diarrhea
• Rash
• Headache
• Nausea
• Fever
• Vomiting

Serious side effects are rare with Atovaquone. Contact your healthcare provider immediately if you experience any of the following.

• Allergic reaction

The following medications may interact with Atovaquone:

• Concomitant administration of rifampin or rifabutin reduces Atovaquone concentrations; concomitant use with Atovaquone oral suspension is not recommended
• Concomitant administration of tetracycline reduces Atovaquone concentrations; use caution when coadministering. Monitor patients for potential loss of efficacy of Atovaquone if coadministration of tetracycline is necessary
• Concomitant administration with metoclopramide reduces Atovaquone concentrations; administer concomitantly only if other antiemetics are not available.
• Concomitant administration of indinavir reduces indinavir trough concentrations; use caution when coadministering. Monitor patients for potential loss of efficacy of indinavir if coadministration is necessary

Various FDA-approved generic manufacturers

It is not known if Atovaquone will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.

• Mepron