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Atogepant is available as 10 mg, 30 mg, and 60 mg oral tablet.

• Atogepant is a calcitonin gene-related peptide (CGRP) receptor blocker that is used in the prevention of migraines in adults

Atogepant is a calcitonin gene-related peptide (CGRP) receptor blocker. This means it blocks a protein called CGRP in the brain and nervous system. CGRP is thought to be involved with migraines and causing inflammation and pain. By blocking the protein’s activity, Atogepant can help prevent migraine attacks.

Atogepant is typically dosed as follows:

• Episodic migraines (migraines that occur on fewer than 15 days per month): The typical dose is 10 mg, 30 mg, or 60 mg by mouth once per day
• Chronic migraines (migraines that occur on 15 or more days per month): The typical dose is 60 mg by mouth once per day
• Your dose might differ depending on whether you’re taking another medication that interacts with Atogepant and whether you have kidney problems

Atogepant is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Atogepant:

• Nausea
• Constipation
• Fatigue or sleepiness
• Low appetite
• Dizziness

Serious side effects are rare with Atogepant. Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing

The following medications may interact with Atogepant:

• Recommended dosage modifications:
• Strong CYP3A4 Inhibitor:
• Episodic migraine: 10 mg once daily
• Chronic migraine: avoid use
• Strong, Moderate, or Weak CYP3A4 Inducers:
• Episodic migraine: 30 mg or 60 mg once daily
• Chronic migraine: avoid use
• OATP Inhibitors:
• Episodic migraine: 10 mg or 30 mg once daily
• Chronic migraine: 30 mg once daily

Various FDA-approved generic manufacturers

Based on animal data, Atogepant may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant. Atogepant should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

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