ACTEMRA
Used for Rheumatoid Arthritis
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Manufactured by Genentech, Inc.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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ACTEMRA Uses, Side Effects, Interactions, Warnings & Dosing
What is ACTEMRA?
ACTEMRA is the brand name for tocilizumab IV or subcutaneous injection.
What dosages is ACTEMRA available in?
ACTEMRA is available in the following:
- Intravenous Infusion: 80 mg/4 mL (20 mg/mL), 200 mg/10 mL (20 mg/mL), 400 mg/20 mL (20 mg/mL) in single-dose vials for further dilution prior to
intravenous infusion - Subcutaneous Injection: 162 mg/0.9 mL in a single-dose prefilled syringe or single-dose prefilled ACTPen autoinjector
What is ACTEMRA used for?
ACTEMRA is an interleukin-6 (IL-6) receptor antagonist used to treat:
- Moderate-to-severe rheumatoid arthritis (RA) in adults
- Giant cell arteritis (GCA) in adults (Actemra brand only)
- Systemic sclerosis-associated interstitial lung disease (SSc-ILD) in adults (Actemra brand only)
- Polyarticular juvenile idiopathic arthritis (PJIA) in people ages 2 years and older
- Systemic juvenile idiopathic arthritis (SJIA) in people ages 2 years and older
- Cytokine release syndrome (CRS) in people ages 2 years and older (Actemra brand only)
- COVID-19 infection in hospitalized adults who are receiving corticosteroids and require oxygen, mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) (Actemra brand only)
How does ACTEMRA work?
ACTEMRA is an interleukin-6 (IL-6) receptor antagonist. It blocks a chemical released by your immune system called IL-6 that causes inflammation and fever.
How do I take ACTEMRA?
ACTEMRA is given as an infusion through the veins (intravenous or IV) over 1 hour or may also be given as an injection under the skin (subcutaneous or SC). Your provider will decide your dose based on how well the medication is working for you, your body weight, if it’s being given as an IV or SC injection, and if it’s causing side effects.
Is it safe for me to take ACTEMRA?
ACTEMRA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
ACTEMRA Common Side Effects
Common side effects of ACTEMRA:
- Upper respiratory tract infections
- Headache
- High blood pressure
- Higher liver enzymes
ACTEMRA Serious Side Effects
Serious side effects are rare with ACTEMRA. Contact your healthcare provider immediately if you experience any of the following.
- Serious infections: fever, tiredness, chills, cough, trouble breathing
- Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing
- Worsening liver problems or liver failure: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
- Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing
Effects of other drugs, drug classes and over-the-counter products on ACTEMRA
- The following medications may interact with ACTEMRA:
- Exercise caution when coadministering ACTEMRA with CYP3A4 substrate drugs where decrease in effectiveness is undesirable, e.g., oral contraceptives, lovastatin, atorvastatin, etc. The effect of tocilizumab on CYP450 enzyme activity may persist for several weeks after stopping therapy
- Avoid use of live vaccines concurrently with ACTEMRA.
Who makes ACTEMRA?
Genentech, Inc.
Is ACTEMRA safe in pregnancy?
ACTEMRA may harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with ACTEMRA. Genentech has a registry for pregnant women who take ACTEMRA. The purpose of this registry is to check the health of the pregnant mother and her baby. If you are pregnant or become pregnant while taking ACTEMRA, talk to your healthcare provider about how you can join this pregnancy registry or you may contact the registry at 1-877-311-8972 to enroll.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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