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Xromi (hydroxyurea) is an oral solution that is used to reduce the frequency of painful crises and reduce the need for blood transfusions in sickle cell anemia patients.

Xromi is available as a 100 mg/mL oral solution in a 150 mL multiple-dose bottle.

Xromi is an antimetabolite indicated to reduce the frequency of painful crises and reduce the need for blood transfusions in pediatric patients aged 6 months of age to less than 2 years with sickle cell anemia with recurrent moderate to severe painful crises.

Xromi contains hydroxyurea, which is thought to work to reduce the frequency of painful sickle cell crises by promoting the release of cells containing fetal hemoglobin from the bone marrow, which then makes the red blood cells less likely to become sickle-shaped.

The dose of Xromi is based on your weight and given once daily. Your dose may be decreased if you have kidney impairment.

Xromi is a safe and effective treatment when used for FDA approved indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you have an allergy to hydroxyurea or any other component of its formulation.

Common side effects of Xromi: Low platelets, Low white blood cells

Serious side effects are rare with Xromi. Contact your healthcare provider immediately if you experience any of the following: Bone marrow suppression Anemia Increased risk of cancer Lung problems such as pulmonary fibrosis, lung infiltration, pneumonitis, and alveolitis

The following medications may interact with Xromi: Antiretroviral drugs such as didanosine, with or without stavudine

Nova Laboratories, Ltd.

Xromi is not approved approved in males or females who can become pregnant or cause pregnancy. You shoud use effective contraception during and after treatment with Xromi for at least 6 months after therapy. Males should use effective contraception during and after treatment with Xromo for at least 6 months after therapy.

• Hydroxyurea