vandetanib
Used for Cancer
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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vandetanib Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is vandetanib available in?
vandetanib is available as a 100 mg and 300 mg oral tablet.
What is vandetanib used for?
vandetanib is a kinase inhibitor that is used to treat medullary thyroid cancer that can’t be treated with surgery or has spread to other areas of the body.
How does vandetanib work?
vandetanib is a targeted therapy called a tyrosine kinase inhibitor, meaning it stops specific kinases from working. Kinases are enzymes or proteins that send signals to cells, helping them grow. vandetanib works by blocking these signals in cancer cells, which in turn reduces their blood supply, slows their growth, and hinders their ability to survive.
How do I take vandetanib?
The typical dose is 300 mg by mouth once a day, with or without food. Your dose might be different if you have kidney problems or experience certain side effects.
Is it safe for me to take vandetanib?
vandetanib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have congenital long QT syndrome.
vandetanib Common Side Effects
Common side effects of vandetanib:
- Diarrhea
- Rash
- Acne
- High blood pressure
- Nausea
- Headache
- Fatigue
- Upper respiratory infection
- Poor appetite
- Stomach pain
vandetanib Serious Side Effects
Serious side effects are rare with vandetanib. Contact your healthcare provider immediately if you experience any of the following.
- Abnormal heart rhythm (QT prolongation): chest pounding, short of breath, chest pain, feeling faint, lightheaded, dizzy, heart beating fast
- Severe allergic or skin reactions: rash, peeling of skin, hives, trouble breathing, swollen lymph nodes
- Lung damage (interstitial lung disease): shortness of breath, fever, lasting dry cough
- Stroke: weakness or numbness in your arm, legs, or face on one side of the body, trouble speaking, blurred vision, dizziness, loss of balance, trouble walking, confusion
- Serious bleeds: bleeding or bruises that doesn’t stop or go away, large amount of bleeding, blood in the urine, bloody or black and tarry stool
- Heart failure: swelling, shortness of breath, coughing, wheezing, fatigue, weight changes
- Posterior reversible encephalopathy syndrome (PRES): severe headaches, seizures, confusion, changes in vision, difficulty staying awake, trouble speaking
- Kidney problems: swelling, less urination, nausea, fatigue, metallic taste changes, cramps
Effects of other drugs, drug classes and over-the-counter products on vandetanib
The following medications may interact with vandetanib:
- Avoid the use of strong CYP3A4 inducers because they may decrease
- vandetanib exposure
- Avoid the use of agents that prolong the QT interval
Who makes vandetanib?
Various FDA-approved generic manufacturers
Is vandetanib safe in pregnancy?
vandetanib can cause harm to your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant. Females who are able to become pregnant:
Your healthcare provider should do a pregnancy test before you begin treatment with vandetanib. You should use effective birth control during your treatment with vandetanib and for at least 4 months after your last dose of vandetanib. Talk to your healthcare provider about birth control methods to prevent pregnancy while you are taking vandetanib.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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