ustekinumab
Used for Psoriasis
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Manufactured by various FDA-approved generic manufacturers.
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ustekinumab Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is ustekinumab available in?
ustekinumab is available in the following:
Subcutaneous Injection
45 mg/0.5 mL or 90 mg/mL solution in a single-dose prefilled
syringe
45 mg/0.5 mL solution in a single-dose vial
Intravenous Infusion
130 mg/26 mL (5 mg/mL) solution
What is ustekinumab used for?
- ustekinumab is an interleukin antagonist that is used to treat:
- Moderate-to-severe plaque psoriasis (Ps) in adults and children ages 6 years and older
- Psoriatic arthritis (PsA) in adults and children ages 6 years and older
- Moderate-to-severe Crohn’s disease (CD) in adults
- Moderate-to-severe ulcerative colitis (UC) in adults
How does ustekinumab work?
ustekinumab is an interleukin antagonist. It blocks proteins in your immune system called interleukin-12 (IL-12) and interleukin-23 (IL-23) from working. This helps to lower inflammation and treat symptoms caused by autoimmune conditions.
How do I take ustekinumab?
- ustekinumab is typiically dosed as follows:
- Plaque psoriasis
- Adults:
- Weight 220 lbs or less: The typical dose is 45 mg injected under the skin once, then another 45 mg four weeks later. After the second dose, 45 mg is injected every 12 weeks.
- Weight more than 220 lbs: The typical dose is 90 mg injected under the skin once, then another 90 mg four weeks later. After the second dose, 90 mg is injected every 12 weeks.
- Children ages 6 to under 18 years:
- Weight less than 132 lbs: The typical dose is 0.75 mg/kg of body weight injected under the skin once, then another 0.75 mg/kg four weeks later. After the second dose, 0.75 mg/kg is injected every 12 weeks.
- Weight of 132 lbs to 220 lbs: The typical dose is 45 mg injected under the skin once, then another 45 mg four weeks later. After the second dose, 45 mg is injected every 12 weeks.
- Weight more than 220 lbs: The typical dose is 90 mg injected under the skin once, then another 90 mg four weeks later. After the second dose, 90 mg is injected every 12 weeks.
- Psoriatic arthritis
- Adults:
- Psoriatic arthritis only: The typical dose is 45 mg injected under the skin once, then another 45 mg four weeks later. After the second dose, 45 mg is injected every 12 weeks.
- Psoriatic arthritis with plaque psoriasis and weighing more than 220 lbs: The typical dose is 90 mg injected under the skin once, then another 90 mg four weeks later. After the second dose, 90 mg is injected every 12 weeks.
- Children ages 6 to under 18 years:
- Weight less than 132 lbs: The typical dose is 0.75 mg/kg of body weight injected under the skin once, then another 0.75 mg/kg four weeks later. After the second dose, 0.75 mg/kg is injected every 12 weeks.
- Weight of 132 lbs or more: The typical dose is 45 mg injected under the skin once, then another 45 mg four weeks later. After the second dose, 45 mg is injected every 12 weeks.
- Psoriatic arthritis with plaque psoriasis and weighing more than 220 lbs: The typical dose is 90 mg injected under the skin once, then another 90 mg four weeks later. After the second dose, 90 mg is injected every 12 weeks.
- Crohn’s disease and ulcerative colitis:
- Adults: The typical dose is 260 mg to 520 mg infusion into the veins (intravenous, IV) once, then 90 mg under the skin every 8 weeks.
Is it safe for me to take ustekinumab?
ustekinumab is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
ustekinumab Common Side Effects
- Common side effects of ustekinumab:
- Inflammation of the nasal passages
- Upper respiratory tract infection
- Headache
- Joint pain
- Nausea
- Redness at the injection site
- Yeast infection
- Bronchitis
- Stomach pain
- Flu infection
- Fever
ustekinumab Serious Side Effects
Serious side effects are rare with ustekinumab. Contact your healthcare provider immediately if you experience any of the following.
Serious infection: fever, cough, weight loss, muscle aches, dark urine, chills, vomiting
Severe allergic reaction: rash; trouble breathing; swelling of your face, eyes, lips, or mouth; hives
Posterior reversible encephalopathy syndrome (PRES): headache, feeling sluggish or confused, vision changes, seizure
Swelling in the lungs: trouble breathing, cough
Effects of other drugs, drug classes and over-the-counter products on ustekinumab
- The following medications may interact with ustekinumab:
- Upon initiation of ustekinumab in patients who are receiving concomitant CYP450 substrates, particularly those with
- a narrow therapeutic index, consider monitoring for therapeutic effect (e.g., for warfarin) or drug
- concentration (e.g., for cyclosporine) and adjust the individual dose of the drug as needed.
Who makes ustekinumab?
Various FDA-approved generic manufacturers
Is ustekinumab safe in pregnancy?
It is not known if ustekinumab will harm your unborn baby. If you become pregnant while receiving ustekinumab talk to your healthcare provider.
What to do if you missed your ustekinumab dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Tips
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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