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Tresiba is the brand name for insulin degludec and is available as a subcutaneous injection.

Tresiba is available as a vial, FlexTouch prefilled pen and FlexPen prefilled pen that contains 100 units/ml.

Tresiba is an insulin and is used for the following:

• Type 1 diabetes
• Type 2 diabetes

Tresiba releases a hormone called insulin into the body to lower glucose (sugar) levels in the blood.

Tresiba is dosed as follows:

• Type 1 diabetes: The typical starting dose when using this medication for the first time is 33% to 50% of your total daily insulin requirement
• Type 2 diabetes: The typical starting dose when using this medication for the first time is 10 units once daily.
• Type 1 or 2 diabetes (adult): The typical starting dose is the same total daily long- or intermediate-acting insulin unit dose
• Type 1 or 2 diabetes (child): The typical starting dose is 80% of the total daily long- or intermediate-acting insulin unit dose

Tresiba is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• During episodes of hypoglycemia.
• Hypersensitivity to insulin degludec or any of the excipients in Tresiba

Common side effects of Tresiba:

• Type 1 diabetes:
• Low blood sugar
• Common cold involving the nose, throat, and lungs
• Headache
• Inflammation of the sinuses
• Stomach flu
• Type 2 diabetes:
• Low blood sugar
• Common cold involving the nose, throat, and lungs
• Headache
• Diarrhea

Serious side effects are rare with Tresiba. Contact your healthcare provider immediately if you experience any of the following.

• Severe hypoglycemia (dangerously low blood sugar) – If not treated, severe hypoglycemia can lead to unconsciousness, seizures, and even death
• Severe allergic reactions
• Dangerously low levels of potassium

The following medications may interact with Tresiba:

• Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g. octreotide), and sulfonamide antibiotics
• Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics, corticosteroids, danazol, diuretics estrogens, glucagon, isoniazid, niacin, oral contraceptives phenothiazines, progestogens (e.g., in oral contraceptives) protease inhibitors, somatropin, sympathomimetic agents (e.g. albuterol, epinephrine, terbutaline), and thyroid hormones.
• Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine
• Drugs that may blunt the signs and symptoms of hypoglycemia: beta-blockers, clonidine, guanethidine, and reserpine

Novo Nordisk Inc.

Published studies with Tresiba used during pregnancy have not reported an association between it use and the induction of major birth defects, miscarriage, or adverse maternal or fetal outcomes. If you become pregnant while receiving Tresiba, talk to your healthcare provider.

• Insulin Degludec