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teriflunomide Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is teriflunomide available in?

What dosages is teriflunomide available in?

teriflunomide is available as a 7 mg and 14 mg film-coated oral tablet.

What is teriflunomide used for?

What is teriflunomide used for?

teriflunomide is a pyrimidine synthesis inhibitor that is used to treat relapsing forms of multiple sclerosis (MS).

How does teriflunomide work?

How does teriflunomide work?

teriflunomide is a type of disease-modifying treatment (DMT) called a pyrimidine synthesis inhibitor. The exact way it works to treat MS isn’t well-understood. But it’s thought to calm down the immune system by blocking a specific enzyme (protein).

How do I take teriflunomide?

How do I take teriflunomide?

teriflunomide is typically taken by mouth once daily, with or without food.

Is it safe for me to take teriflunomide?

Is it safe for me to take teriflunomide?

teriflunomide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you are pregnant, have severe hepatic impairment, or are currently on leflunomide treatment.

teriflunomide Common Side Effects

teriflunomide Common Side Effects

Common side effects of teriflunomide include:

  • Headache
  • Abnormal liver tests
  • Diarrhea
  • Hair loss
  • Nausea
teriflunomide Serious Side Effects

teriflunomide Serious Side Effects

Serious side effects are rare with teriflunomide. Contact your healthcare provider immediately if you experience any of the following.

  • Liver problems: nausea, vomiting, stomach pain, swelling of your stomach, yellowing of your skin or the whites of your eyes, clay-colored stool, confusion
  • Infections: fever, difficulty breathing, diarrhea, weakness, cough, stomach pain, sweating, chills
  • Serious allergic and skin reactions: sore throat, fever, fatigue, rash, hives, painful blisters, skin reddening, skin peeling, swollen lymph nodes
Effects of other drugs, drug classes and over-the-counter products on teriflunomide

Effects of other drugs, drug classes and over-the-counter products on teriflunomide

The following medications may interact with teriflunomide:

  • Drugs metabolized by CYP2C8 and OAT3 transporters – May increase the levels of these drugs
  • Oral contraceptives – May increase levels of ethinylestradiol and levonorgestrel
  • Drugs metabolized by CYP1A2 – May decrease the levels of these drugs.
  • • Warfarin: Monitor INR as INR may be decreased
  • • Drugs metabolized by BCRP and OATP1B1/B3 transporters: May increase levels of these drugs
  • • Rosuvastatin: The dose of rosuvastatin should not exceed 10 mg once daily in patients taking teriflunomide
Who makes teriflunomide?

Who makes teriflunomide?

Various FDA-approved generic manufacturers

Is teriflunomide safe in pregnancy?

Is teriflunomide safe in pregnancy?

teriflunomide may cause harm to your unborn baby. You should take a pregnancy test before starting this medication. Use effective contraception if you can become pregnant during treatment and during a drug elimination procedure. Stop teriflunomide and use an accelerated drug elimination procedure if you become pregnant.


What to do if you missed your teriflunomide dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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