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Tegsedi is the brand name for inotersen and is available as a subcutaneous injection.

Tegsedi is available as a 284 mg/1.5 mL single-dose prefilled syringe.

Tegsedi is a medication used to treat polyneuropathy from hereditary transthyretin-mediated amyloidosis (hATTR).

Tegsedi is a transthyretin-directed antisense oligonucleotide. It works by preventing the creation of misshapened TTR proteins, which lowers the amount of amyloid that builds up.

The recommended dose of Tegsedi is 284 mg injected under the skin once weekly.

Tegsedi is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Low platelet count
• History of glomerulonephritis (kidney damage) from Tegsedi
• History of a hypersensitivity reaction to Tegsedi

Common side effects of Tegsedi:

• Injection site reactions
• Nausea
• Headache
• Fatigue
• Low platelet count
• Fever
• Swelling in hands, feet, or ankles
• Chills
• Low red blood cells
• Vomiting
• Muscle pain

Serious side effects are rare with Tegsedi. Contact your healthcare provider immediately if you experience any of the following:

• Low platelet count: unusual bleeding or bruising, bleeding that lasts for a long time, difficulty stopping bleeds, blood in vomit, urine, or stool, dizziness, lightheadedness
• Kidney damage: puffy face, dark or brown-colored urine, urinating less frequently, swelling of ankles, frequent urination at night, bubbly or foamy urine, lack of appetite
• Liver damage: yellowing of your skin or the whites of your eyes, fatigue, low appetite, nausea, vomiting, stomach discomfort
• Stroke: sudden trouble speaking, droopy face, sudden confusion, numbness or weakness in the face, arm, or leg
• Allergic reaction: chest pain, chills, flushing, joint or muscle pain, flu-like symptoms, difficulty swallowing, redness in the palms of your hands, jerking movements

The following medications may interact with Tegsedi:

• Antiplatelet drugs (e.g., adenosine, clopidogrel, prasugrel, ticagrelor, or ticlopidine, aspirin, nonsteroidal anti-inflammatory drugs)
• Anticoagulants (e.g., heparin, warfarin)
• Drugs that may impair kidney function

Akcea Therapeutics

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Inotersen