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Sulindac is available as a 150 mg and 200 mg oral tablet.

Sulindac is an NSAID used to treat:

• Osteoarthritis
• Rheumatoid arthritis
• Arthritis of the spine (ankylosing spondylitis)
• Gout (gouty arthritis)
• Acute shoulder pain

Sulindac is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking proteins in your body that cause pain and swelling.

The typical dose starts at 150 mg or 200 mg by mouth twice daily with food. The maximum daily dose is 400 mg.

Sulindac is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Asthma, hives, or allergic reactions after taking aspirin or other NSAIDs
• Heart bypass surgery

Common side effects of Sulindac:

• Stomach pain
• Heartburn
• Nausea
• Diarrhea
• Constipation
• Rash
• Dizziness
• Headache

Serious side effects are rare with Sulindac. Contact your healthcare provider immediately if you experience any of the following:

• Heart attack: dizziness, tiredness, cold sweat, trouble breathing, chest pain or tightness, anxiety
• Stroke: tiredness, lightheadedness, blurred vision, difficulty speaking, difficulty walking, weakness on one side of the body
• Stomach bleeds: blood in your vomit, stool that looks like black coffee grounds, pain in your stomach that doesn’t go away
• Heart failure: trouble breathing, tiredness, swelling in your body, sudden weight gain
• Kidney damage: nausea, vomiting, tiredness, loss of appetite, changes in how much you urinate
• Liver damage: fever, chills, fatigue, nausea, vomiting, yellowing of the skin or whites of the eyes, clay-colored stool, and dark urine
• Severe asthma attack: chest pain, cough, difficulty breathing, wheezing
• Serious allergic and skin reaction: fever, rash, body aches, cough, swelling of the face, peeling skin, painful blisters all over your bodyHeart attack: dizziness, tiredness, cold sweat, trouble breathing, chest pain or tightness, anxiety
• Stroke: tiredness, lightheadedness, blurred vision, difficulty speaking, difficulty walking, weakness on one side of the body
• Stomach bleeds: blood in your vomit, stool that looks like black coffee grounds, pain in your stomach that doesn’t go away
• Heart failure: trouble breathing, tiredness, swelling in your body, sudden weight gain
• Kidney damage: nausea, vomiting, tiredness, loss of appetite, changes in how much you urinate
• Liver damage: fever, chills, fatigue, nausea, vomiting, yellowing of the skin or whites of the eyes, clay-colored stool, and dark urine
• Severe asthma attack: chest pain, cough, difficulty breathing, wheezing
• Serious allergic and skin reaction: fever, rash, body aches, cough, swelling of the face, peeling skin, painful blisters all over your body

The following medications may interact with Sulindac:

• ACE-inhibitors and angiotensin II antagonists
• Other NSAIDs
• Cyclosporine
• Diflunisal
• Diuretics
• Lithium
• Methotrexate
• Anticoagulants
• Probenecid

Various FDA-approved generic manufacturers

In late pregnancy, as with other NSAIDs, Sulindac should be avoided because it may cause harm to your unborn baby. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

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