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Spironolactone/HCTZ is available as a 25 mg/25 mg and 50 mg/50 mg tablet.

Spironolactone/HCTZ is a combination medicine used to treat hypertension or swelling due to liver damage (cirrhosis), nephrotic syndrome (a rare kidney condition), or congestive heart failure.

Spironolactone/HCTZ contains spironolactone, which is a potassium-sparing diuretic (water pill) that works in your kidneys you urinate more without lowering the amount of potassium. This helps lower the amount of fluid in your blood vessels and other areas of your body. It also contains hydrochlorothiazide, which is a thiazide diuretic (water pill) that makes you urinate more. It works in your kidneys to remove extra water and certain electrolytes (like sodium and potassium), which helps lower your blood pressure and decrease swelling throughout your body.

Spironolactone/HCTZ can be taken as a single dose once a day or split into smaller doses and be taken twice a day.

Spironolactone/HCTZ is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Spironolactone/HCTZ is contraindicated in patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, hypercalcemia, hyperkalemia, Addison’s disease, and in patients who are allergic to thiazide diuretics or to other sulfonamide-derived drugs. Spironolactone/HCTZ may also be contraindicated in acute or severe liver failure.

Common side effects of Spironolactone/HCTZ include:

• Enlargement of a man’s breasts
• Dizziness
• Low blood pressure
• Sensitivity to the sun

Serious side effects are rare with Spironolactone/HCTZ. Contact your healthcare provider immediately if you experience any of the following.

• Stevens-Johnson Syndrome and toxic epidermal necrolysis (rare, but life-threatening skin disorders)
• High levels of potassium in the blood
• Kidney failure
• Severe allergic reactions

ACE inhibitors, Angiotensin II receptor antagonists, aldosterone blockers, potassium supplements, heparin, low molecular weight heparin, and other drugs known to cause hyperkalemia. Alcohol, barbiturates, or narcotics: Potentiation of orthostatic hypotension may occur. Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia, may occur. Nonsteroidal anti-inflammatory drugs (NSAIDs): In some patients, the administration of an NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Combination of NSAIDs, e.g., indomethacin, with potassium-sparing diuretics has been associated with severe hyperkalemia. Lithium: Lithium generally should not be given with diuretics. Diuretics: May reduce the renal clearance of lithium and add a high risk of lithium toxicity. Cholestyramine: Hyperkalemic metabolic acidosis has been reported with concomitant use.

Various FDA-approved generic manufacturers

It is not known if Spironolactone/HCTZ will harm your unborn baby. If you become pregnant while receiving Spironolactone/HCTZ, talk to your healthcare provider.

• Aldactazide