Used for Hypertension

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

spironolactone/hctz Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is spironolactone/hctz available in?

What dosages is spironolactone/hctz available in?

spironolactone/HCTZ is available as a 25 mg/25 mg and 50 mg/50 mg tablet.

What is spironolactone/hctz used for?

What is spironolactone/hctz used for?

spironolactone/HCTZ is a combination medicine used to treat hypertension or swelling due to liver damage (cirrhosis), nephrotic syndrome (a rare kidney condition), or congestive heart failure.

How does spironolactone/hctz work?

How does spironolactone/hctz work?

spironolactone/HCTZ contains spironolactone, which is a potassium-sparing diuretic (water pill) that works in your kidneys you urinate more without lowering the amount of potassium. This helps lower the amount of fluid in your blood vessels and other areas of your body. It also contains hydrochlorothiazide, which is a thiazide diuretic (water pill) that makes you urinate more. It works in your kidneys to remove extra water and certain electrolytes (like sodium and potassium), which helps lower your blood pressure and decrease swelling throughout your body.

How do I take spironolactone/hctz?

How do I take spironolactone/hctz?

spironolactone/HCTZ can be taken as a single dose once a day or split into smaller doses and be taken twice a day.

Is it safe for me to take spironolactone/hctz?

Is it safe for me to take spironolactone/hctz?

spironolactone/HCTZ is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. spironolactone/HCTZ is contraindicated in patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, hypercalcemia, hyperkalemia, Addison’s disease, and in patients who are allergic to thiazide diuretics or to other sulfonamide-derived drugs. spironolactone/HCTZ may also be contraindicated in acute or severe liver failure.

spironolactone/hctz Common Side Effects

spironolactone/hctz Common Side Effects

Common side effects of spironolactone/HCTZ include:

  • Enlargement of a man’s breasts
  • Dizziness
  • Low blood pressure
  • Sensitivity to the sun
spironolactone/hctz Serious Side Effects

spironolactone/hctz Serious Side Effects

Serious side effects are rare with spironolactone/HCTZ. Contact your healthcare provider immediately if you experience any of the following.

  • Stevens-Johnson Syndrome and toxic epidermal necrolysis (rare, but life-threatening skin disorders)
  • High levels of potassium in the blood
  • Kidney failure
  • Severe allergic reactions
Effects of other drugs, drug classes and over-the-counter products on spironolactone/hctz

Effects of other drugs, drug classes and over-the-counter products on spironolactone/hctz

ACE inhibitors, Angiotensin II receptor antagonists, aldosterone blockers, potassium supplements, heparin, low molecular weight heparin, and other drugs known to cause hyperkalemia. Alcohol, barbiturates, or narcotics: Potentiation of orthostatic hypotension may occur. Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia, may occur. Nonsteroidal anti-inflammatory drugs (NSAIDs): In some patients, the administration of an NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Combination of NSAIDs, e.g., indomethacin, with potassium-sparing diuretics has been associated with severe hyperkalemia. Lithium: Lithium generally should not be given with diuretics. Diuretics: May reduce the renal clearance of lithium and add a high risk of lithium toxicity. Cholestyramine: Hyperkalemic metabolic acidosis has been reported with concomitant use.

Who makes spironolactone/hctz?

Who makes spironolactone/hctz?

Various FDA-approved generic manufacturers

Is spironolactone/hctz safe in pregnancy?

Is spironolactone/hctz safe in pregnancy?

It is not known if spironolactone/HCTZ will harm your unborn baby. If you become pregnant while receiving spironolactone/HCTZ, talk to your healthcare provider.


What to do if you missed your spironolactone/hctz dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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