spironolactone/hctz
Used for Hypertension
NowPatient can significantly lower the cost* of your prescription medication by providing free access to drug coupons, savings cards, patient assistance programs and other out of pocket discount programs. Whether you’re insured, uninsured, or underinsured, we empower you with transparency and cost-saving tools to make your spironolactone/hctz more affordable.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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spironolactone/hctz key facts
What dosages is spironolactone/hctz available in?
spironolactone/HCTZ is available as a 25 mg/25 mg and 50 mg/50 mg tablet.
What is spironolactone/hctz used for?
spironolactone/HCTZ is a combination medicine used to treat hypertension or swelling due to liver damage (cirrhosis), nephrotic syndrome (a rare kidney condition), or congestive heart failure.
How does spironolactone/hctz work?
spironolactone/HCTZ contains spironolactone, which is a potassium-sparing diuretic (water pill) that works in your kidneys you urinate more without lowering the amount of potassium. This helps lower the amount of fluid in your blood vessels and other areas of your body. It also contains hydrochlorothiazide, which is a thiazide diuretic (water pill) that makes you urinate more. It works in your kidneys to remove extra water and certain electrolytes (like sodium and potassium), which helps lower your blood pressure and decrease swelling throughout your body.
How do I take spironolactone/hctz?
spironolactone/HCTZ can be taken as a single dose once a day or split into smaller doses and be taken twice a day.
Is it safe for me to take spironolactone/hctz?
spironolactone/HCTZ is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. spironolactone/HCTZ is contraindicated in patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, hypercalcemia, hyperkalemia, Addison’s disease, and in patients who are allergic to thiazide diuretics or to other sulfonamide-derived drugs. spironolactone/HCTZ may also be contraindicated in acute or severe liver failure.
spironolactone/hctz Common Side Effects
Common side effects of spironolactone/HCTZ include:
- Enlargement of a man’s breasts
- Dizziness
- Low blood pressure
- Sensitivity to the sun
spironolactone/hctz Serious Side Effects
Serious side effects are rare with spironolactone/HCTZ. Contact your healthcare provider immediately if you experience any of the following.
- Stevens-Johnson Syndrome and toxic epidermal necrolysis (rare, but life-threatening skin disorders)
- High levels of potassium in the blood
- Kidney failure
- Severe allergic reactions
Effects of other drugs, drug classes and over-the-counter products on spironolactone/hctz
ACE inhibitors, Angiotensin II receptor antagonists, aldosterone blockers, potassium supplements, heparin, low molecular weight heparin, and other drugs known to cause hyperkalemia. Alcohol, barbiturates, or narcotics: Potentiation of orthostatic hypotension may occur. Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia, may occur. Nonsteroidal anti-inflammatory drugs (NSAIDs): In some patients, the administration of an NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Combination of NSAIDs, e.g., indomethacin, with potassium-sparing diuretics has been associated with severe hyperkalemia. Lithium: Lithium generally should not be given with diuretics. Diuretics: May reduce the renal clearance of lithium and add a high risk of lithium toxicity. Cholestyramine: Hyperkalemic metabolic acidosis has been reported with concomitant use.
Who makes spironolactone/hctz?
Various FDA-approved generic manufacturers
Is spironolactone/hctz safe in pregnancy?
It is not known if spironolactone/HCTZ will harm your unborn baby. If you become pregnant while receiving spironolactone/HCTZ, talk to your healthcare provider.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription drug costs
How can NowPatient help me to lower the cost of my spironolactone/hctz prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your spironolactone/hctz prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient spironolactone/hctz savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient spironolactone/hctz savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for spironolactone/hctz | Canadian Prescription Savings* for spironolactone/hctz | spironolactone/hctz Drug Coupon* | spironolactone/hctz Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of spironolactone/hctz?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for spironolactone/hctz | Canadian Prescription Savings* for spironolactone/hctz | spironolactone/hctz Drug Coupon* | spironolactone/hctz Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the spironolactone/hctz savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the spironolactone/hctz drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for spironolactone/hctz, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the spironolactone/hctz prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, spironolactone/hctz is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed spironolactone/hctz for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the spironolactone/hctz prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the spironolactone/hctz prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for spironolactone/hctz
If you are having trouble paying for your spironolactone/hctz medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for spironolactone/hctz you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- spironolactone/hctz is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers spironolactone/hctz
- If spironolactone/hctz is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for spironolactone/hctz
If you are having trouble paying for your spironolactone/hctz medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for spironolactone/hctz you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers spironolactone/hctz
- If spironolactone/hctz is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for spironolactone/hctz
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your spironolactone/hctz treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for spironolactone/hctz you will need to meet the following criteria:
- You must be currently insured and have coverage for spironolactone/hctz
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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You can lower the cost of your prescription medications using our various savings programs which include drug coupons, savings card and manufacturer-sponsored patient assistance programs.
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