Spironolactone Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Spironolactone
    Generic for Aldactone
    30 tablets $4.5 USD
    Save $9.90
  3. Spironolactone
    Generic for Aldactone
    60 tablets $6 USD
    Save $22.80
  4. Spironolactone
    Generic for Aldactone
    90 tablets $8.4 USD
    Save $34.80
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Do you need a prescription for spironolactone?

Yes, spironolactone is only available with a valid physician Rx.

How much is spironolactone without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase spironolactone, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for spironolactone in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a spironolactone savings card?

Yes. Save up to 90% on your spironolactone with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a spironolactone coupon provider in the US?

No. Now Patient does not provide spironolactone coupons or FREE spironolactone samples.

Do you accept commercial, Medicare or Medicaid coverage for spironolactone in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much spironolactone?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using spironolactone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much spironolactone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic spironolactone?

Generic spironolactone refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of spironolactone

Spironolactone is approved by the U.S. Food and Drug Administration (FDA) for the treatment of several conditions, including hypertension, heart failure, and certain hormonal disorders.

Active ingredient of spironolactone

The active ingredient of spironolactone is spironolactone.

US brand name of spironolactone and manufacturer

Spironolactone is available under various brand names in the US, including Aldactone, and CaroSpir. These medications are manufactured by different pharmaceutical companies.

UK brand name of spironolactone and manufacturer

In the UK, spironolactone is available under various brand names, and the manufacturers may vary.

Prescription requirement for spironolactone

A prescription (Rx) is required for spironolactone in both the US and the UK.

Availability of spironolactone in the UK with NHS prescription

Spironolactone is available in the UK with an NHS prescription.

Conditions treated by spironolactone

Spironolactone is used to treat various conditions, including hypertension (high blood pressure), heart failure, edema (fluid retention), and hormonal disorders such as polycystic ovary syndrome (PCOS).

How does spironolactone work?

Spironolactone is a medication that belongs to a class called potassium-sparing diuretics. It works by blocking the effects of a hormone called aldosterone, which helps regulate the balance of salt and water in the body. By blocking aldosterone, spironolactone reduces fluid retention and helps lower blood pressure.

Forms of spironolactone available

Spironolactone is available in the form of oral tablets.

Dosage of spironolactone

The dose of spironolactone may vary depending on the specific condition being treated, the severity of the condition, and individual patient factors. It is important to follow the prescribed dosage instructions provided by the healthcare provider.

Directions for spironolactone use

Spironolactone should be taken exactly as directed by the healthcare provider. The tablets should be swallowed whole with a glass of water. It is usually taken once or twice daily, with or without food.

Warnings and precautions for spironolactone

  • Spironolactone may cause an increase in potassium levels in the blood. Regular monitoring of potassium levels is important, especially in patients with kidney problems or those taking other medications that can affect potassium levels
  • Tell your doctor if you have Addison’s disease (an adrenal gland disorder), electrolyte imbalances such as high levels of potassium or low levels of calcium, sodium or magnesium, in your blood, kidney disease, liver disease, or heart disease
  • It may interact with certain medications, including other diuretics, ACE inhibitors, and nonsteroidal anti-inflammatory drugs (NSAIDs)

Use of spironolactone during pregnancy

Spironolactone is generally not recommended during pregnancy. Consultation with a healthcare provider is necessary to discuss the potential risks and benefits.

Use of spironolactone while breastfeeding

Spironolactone may pass into breast milk and may have adverse effects on the nursing infant. It is generally not recommended while breastfeeding. Consultation with a healthcare provider is necessary to discuss alternative treatment options.

Possible side effects of spironolactone

Common side effects of spironolactone may include dizziness, lightheadedness, drowsiness, headache, stomach upset, and changes in menstrual cycle. Serious side effects are rare but can include hyperkalemia (high potassium levels), allergic reactions, muscle weakness and liver problems. Get medical help right away if you have any serious side effects such as an allergic reaction. Symptoms include hives, trouble breathing, shortness of breath, chest pain, swelling of the face, tongue or throat, skin rash, and severe skin reactions. Promptly report any adverse effects to a healthcare professional for medical advice.

Interactions with other drugs

Spironolactone may interact with certain medications, including eplerenone, angiotensin-converting enzyme (ACE) inhibitors such as lisinopril, angiotensin II antagonists (angiotensin receptor blockers) such as candesartan, nonsteroidal anti-inflammatory medications (NSAIDS) such as ibuprofen and naproxen, digoxin, diuretics (water pills) including potassium-sparing diuretics such as amiloride, lithium, potassium supplements, and trimethoprim. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medication, salt substitutes, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.

Similar drugs to spironolactone

Other medications used to treat hypertension and heart failure include ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers.


  • FDA Prescribing Information for Spironolactone
  • MHRA product information for Spironolactone
  • NHS UK
  • Drugs.com
  • WebMD
Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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