secukinumab
Used for Psoriasis
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Manufactured by various FDA-approved generic manufacturers.
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secukinumab Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is secukinumab available in?
secukinumab is available in the following:
- Subcutaneous Injection
300 mg/2 mL solution in a single-dose UnoReady® pen and in a single-dose prefilled syringe
150 mg/mL solution in a single-dose Sensoready® pen and in a single-dose prefilled syringe
75 mg/0.5 mL solution in a single-dose prefilled syringe (for pediatric patients) Intravenous Infusion - 125 mg/5 mL solution in a single-dose vial
What is secukinumab used for?
secukinumab is an interleukin 17 (IL-17) inhibitor and is used for the following:
- Plaque psoriasis (PsO) in people ages 6 years and older
- Psoriatic arthritis (PsA) in people ages 2 years and older who weigh at least 33 lbs
- Ankylosing spondylitis (AS) in adults
- Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
- Enthesitis-related arthritis in people ages 4 years and older who weigh at least 33 lbs
- Hidradenitis suppurativa in adults
How does secukinumab work?
secukinumab is a monoclonal antibody that works as an interleukin inhibitor. It blocks a protein in your immune system called interleukin-17 (IL-17), which tends to be overly active in certain inflammatory conditions. In doing so, secukinumab lowers swelling, pain, and inflammation.
How do I take secukinumab?
secukinumab is dosed as follows:
Adults
- Plaque psoriasis (PsO) and hidradenitis suppurativa: The typical starting dose is 300 mg injected under the skin weekly for 5 weeks. After that, the maintenance dose is usually 300 mg injected monthly
- Psoriatic arthritis (PsA), ankylosing spondylitis (AS), and non-radiographic axial spondyloarthritis (nr-axSpA): The starting dose can be optional; if given, the typical dose is 150 mg injected under the skin (SQ) weekly for 5 weeks. After that, the maintenance dose is usually 150 mg injected under the skin monthly. If appropriate, your provider might raise your dose to 300 mg monthly
Children
- secukinumab is approved for children to treat PsO (ages 6 years and older), PsA (ages 2 years and older), and enthesitis-related arthritis (ages 4 years and older)
- Body weight 33 lbs to 110 lbs: The typical starting dose is 75 mg injected under the skin weekly for 5 weeks. After that, the maintenance dose is usually 75 mg injected monthly
- Body weight 110 lbs or more: The typical starting dose is 150 mg injected under the skin weekly for 5 weeks. After that, the maintenance dose is usually 150 mg injected monthly
- secukinumab can also be given as an injection through the veins for PsA, AS, and nr-axSpA for adults only. Your provider will calculate the dose based on your body weight. The injection is usually given by a healthcare provider in a clinic setting
Is it safe for me to take secukinumab?
secukinumab is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
secukinumab Common Side Effects
Common side effects of secukinumab:
- Diarrhea
- Upper respiratory infections
- Common cold
secukinumab Serious Side Effects
Serious side effects are rare with secukinumab. Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reactions: difficulty breathing; hives; swelling of your face, lips, tongue, or throat
- Infection: fever; cough; difficulty breathing; diarrhea; weakness; sweating; chills; scaly, itchy, or burning skin
Effects of other drugs, drug classes and over-the-counter products on secukinumab
The following medications may interact with secukinumab:
- Upon beginning or stopping secukinumab in patients who are receiving concomitant CYP450 substrates
- particularly those where minimal decreases in the concentration may reduce CYP substrate effectiveness or minimal increases in the concentration may increase CYP substrate adverse reactions, consider monitoring for therapeutic effect or concentration of the CYP substrate and consider dosage adjustment of the CYP substrate as needed
Who makes secukinumab?
Various FDA-approved generic manufacturers
Is secukinumab safe in pregnancy?
It is not known if secukinumab can harm your unborn baby. You and your healthcare provider should decide if you will use secukinumab.
What to do if you missed your secukinumab dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Tips
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
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