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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

REVLIMID Uses, Side Effects, Interactions, Warnings & Dosing



REVLIMID is the brand name for lenalidomide and is available as an oral capsule.

What dosages is REVLIMID available in?

What dosages is REVLIMID available in?

REVLIMID is available as a 2.5 mg, 5 mg, 10 mg, 15 mg, 20 mg, and 25 mg oral capsule.

What is REVLIMID used for?

What is REVLIMID used for?

REVLIMID is an immunomodulator that is used to treat:

  • Multiple myeloma, with dexamethasone or after stem cell transplant
  • Myelodysplastic syndromes (deletion 5q)
  • Mantle cell lymphoma, relapsed or refractory after 2 prior therapies, including Velcade (bortezomib)
  • Follicular lymphoma, previously treated
  • Marginal zone lymphoma, previously treated
How does REVLIMID work?

How does REVLIMID work?

REVLIMID works by stimulating the immune system to fight cancer cells. It also targets specific proteins within cancer cells and stops the cancer cell from growing. In addition, REVLIMID works by blocking the blood supply to certain tumor cells, which helps lower the growth of new cancer cells.

How do I take REVLIMID?

How do I take REVLIMID?

REVLIMID is dosed as follows:

  • Multiple myeloma and mantle cell lymphoma: The typical dose is 25 mg by mouth once daily for 21 days of a 28-day treatment cycle. If you’re being treated for multiple myeloma, you’ll take lenalidomide in combination with dexamethasone
  • Follicular lymphoma and marginal zone lymphoma: The typical dose is 20 mg by mouth once daily for 21 days of a 28-day treatment cycle, in combination with Rituxan (rituximab), for up to 12 cycles
  • Myelodysplastic syndromes: The typical dose is 10 mg by mouth once daily
  • Your dose might be different if you experience certain side effects, have kidney or liver problems, or you’re taking medications that might interact with REVLIMID
Is it safe for me to take REVLIMID?

Is it safe for me to take REVLIMID?

REVLIMID is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

  • Pregnancy
  • Demonstrated severe hypersensitivity to lenalidomide
REVLIMID Common Side Effects

REVLIMID Common Side Effects

Common side effects of REVLIMID:

  • Diarrhea
  • Low red blood cell count
  • Low neutrophil count
  • Tiredness
  • Back pain
  • Weakness
  • Difficulty sleeping
  • Rash
  • Cough
  • Lowered appetite
  • Trouble breathing
  • Fever
  • Low platelet count
  • Stomach pain
  • Muscle spasms
REVLIMID Serious Side Effects

REVLIMID Serious Side Effects

Serious side effects are rare with REVLIMID. Contact your healthcare provider immediately if you experience any of the following.

  • Serious liver problems: tiredness, loss of appetite, nausea or vomiting, dark urine, right-side stomach pain, easy bruising or bleeding, or yellowing of the eyes or skin
  • Blood clot in the brain: weakness or numbness in your arms, legs, or face on one side of the body, trouble speaking, blurred vision, dizziness, loss of balance, trouble walking, confusion
  • Heart attack: feeling tired, dizziness, chest pain, sweating, nausea
  • Blood clot in the lungs: dizziness, cough, coughing up blood, trouble breathing, chest pain, pounding heart
    Blood clot in the legs: cramps, swelling, pain, or muscle tightness
  • Severe skin reactions: painful blisters, skin wounds, peeling skin, painful sores in your mouth or around your eyes
  • Tumor lysis syndrome: fever, chills, nausea or vomiting, confusion, trouble breathing, seizures, irregular heartbeat, dark or cloudy urine, muscle or joint pain, unusual tiredness
  • Serious infections: fever, sore throat, chills, headache, body aches, cough
  • Serious bleeds: bleeding that’s difficult to stop, bruises that don’t go away, dark or tarry stool
Effects of other drugs, drug classes and over-the-counter products on REVLIMID

Effects of other drugs, drug classes and over-the-counter products on REVLIMID

The following medications may interact with REVLIMID:

  • Digoxin: Monitor digoxin plasma levels periodically due to increased Cmax and AUC with concomitant REVLIMID therapy
  • Concomitant use of erythropoietin stimulating agents or estrogen containing therapies with REVLIMID may increase the risk of thrombosis
Who makes REVLIMID?

Who makes REVLIMID?

Bristol-Myers Squibb

Is REVLIMID safe in pregnancy?

Is REVLIMID safe in pregnancy?

REVLIMID is contraindicated in pregnancy. REVLIMID is a thalidomide analogue. Thalidomide is a known human teratogen that causes severe life-threatening birth defects. For females of reproductive potential: Exclude pregnancy before start of treatment. Prevent pregnancy during treatment by the use of 2 reliable methods of contraception.


What to do if you missed your REVLIMID dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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