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Regadenoson is available as a 0.4 mg/5 mL (0.08 mg/mL) single-dose pre-filled syringe.

Regadenoson is a pharmacologic stress agent used for radionuclide myocardial perfusion imaging (MPI) in patients who can’t undergo an exercise stress test.

Regadenoson is an adenosine receptor agonist that is used as a diagnostic agent. It acts like adenosine, a chemical in your body that raises the amount of blood flow to your heart. During a stress test, Regadenoson mimics this rise in blood flow to the heart to helps doctors locate any areas of heart damage.

The recommended dose of Regadenoson is 5 mL (0.4 mg Regadenoson) given as an intravenous injection over 10 seconds.

Regadenoson is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Second- or third-degree AV block, or sinus node dysfunction (unless they have a functioning artificial pacemaker)

Common side effects of Regadenoson:

• Shortness of breath
• Headache
• Redness or flushing
• Chest pain or discomfort
• Dizziness

Serious side effects are rare with Regadenoson. Contact your healthcare provider immediately if you experience any of the following:

• Worsened heart problems: chest pain, racing heartbeat, dizziness, fainting
• Breathing problems: trouble breathing, coughing, wheezing, shortness of breath
• Seizure
• Stroke: sudden numbness or weakness in the face, arm, or leg, especially on one side of the body; sudden confusion; sudden trouble speaking or understanding speech
• Allergic reaction: throat tightness, rash, puffy or swollen face (especially around your eyes and mouth)

The following medications may interact with Regadenoson:

• Methylxanthines, such as caffeine, aminophylline and theophylline Dipyridamole

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Lexiscan