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Panzyga is the brand name for immune globulin and is available as an IV infusion.

Panzyga is available as a solution containing 10% IgG (100 mg/mL) for an IV infusion.

Panzyga is an Immune globulin and is used for the following:
Conditions where your immune system is missing or not working as it should:

• Trouble fighting infections (primary humoral immunodeficiency or PI)
• Low platelets (chronic (long-term) immune thrombocytopenia or ITP)
• Nerve damage (chronic inflammatory demyelinating polyneuropathy or CIDP)

Panzyga is a replacement for immunoglobulin G (IgG). IgG is an antibody that your immune system makes to help protect against organisms like viruses, bacteria, and fungi. Certain medical conditions can cause your immune system to be too active or too inactive. The exact way Panzyga works to treat these medical conditions isn’t fully known. It’s thought to boost your immune system to help prevent infections. It also might help prevent an overly active immune system from attacking parts of your own body by mistake.

Your dose of Panzyga depends on things like your body weight, lab results, and what you’re using Panzyga for. In general:

Trouble fighting infections (PI)

• Adults and children age 2 years and older: The typical dose is 300 mg/kg to 600 mg/kg infused into the veins (IV) once every 3 to 4 weeks

Low platelets (ITP)

• Adults: The typical dose is 1 gram/kg infused IV once daily for 2 days.

Nerve damage (CIDP)

• Adults: Typically, you’ll start with a loading dose of 1 gram/kg infused IV once daily for 2 days. Then, you’ll continue with a maintenance dose of 1 gram/kg to 2 gram/kg split into 2 doses (1 dose given daily for 2 days in a row), once every 3 weeks.

Panzyga is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• History of anaphylactic or severe systemic reactions to human immune globulin
• IgA-deficient patients with antibodies against IgA and a history of hypersensitivity

Common side effects of Panzyga:

• Stomach pain
• Sinus infection/inflammation
• Extreme tiredness
• Bronchitis
• Headache
• Fever
• Nausea
• Vomiting
• Dizziness
• Weakness, pale-colored skin, or other symptoms of low red blood cell count

Serious side effects are rare with Panzyga. Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reaction: difficulty breathing, hives, itching, fast heartbeat, tightness in the throat, nausea, stomach pain, dizziness, lightheadedness, swelling in the face or tongue
• Swelling in the brain: severe headache, neck stiffness, sensitivity to light, painful eye movements
• Lung problems: severe breathing problems, chest pain or tightness
• Dangerously high blood pressure: severe headache, dizziness, blurry vision, shortness of breath, lightheadedness
• Kidney problems: tiredness, dry and itchy skin, low appetite, urinating less than usual, foamy or bloody urine, muscle cramps
• Blood clots: lungs (cough, difficulty breathing, chest pain); legs (redness, pain, tenderness, swelling of the skin); heart attack (chest pain, pain in the arms or shoulders, pain in the neck or jaw); stroke (difficulty speaking, numbness on one side of the body, confusion)
• Breakdown of red blood cells: tiredness, dizziness, weakness, yellowing of the skin or eyes, dark-colored urine

The following medications may interact with Panzyga:

• The passive transfer of antibodies may confound the results of serological testing
• The passive transfer of antibodies may interfere with the immune response to live viral vaccines, such as measles, mumps, and rubella

Pfizer

It is not known if Panzyga harms your unborn baby. NYVEPRIA should be given to a pregnant woman only if clearly needed. Talk to your doctor about stopping Panzyga if you are pregnant or planning to become pregnant.

• Immune Globulin Intravenous, Human - IFAS