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Nirmatrelvir/Ritonavir is available as an oral tablet that contains nirmatrelvir 150 mg and ritonavir 100 mg.

Nirmatrelvir/Ritonavir is an antiviral and is used to treat Mild-to-moderate COVID-19 in people 12 years and older (and weighing over 88 lbs) who are at high risk for severe illness.

Nirmatrelvir/Ritonavir is a combination of two different medications. Nirmatrelvir is a protease inhibitor. It treats COVID-19 by blocking a certain protease, which is a protein the virus needs to make copies of itself and continue to infect. Ritonavir is also a protease inhibitor. Low-dose ritonavir is included in Nirmatrelvir/Ritonavir to slow the breakdown of nirmatrelvir. This allows nirmatrelvir to stay in your body longer to fight COVID-19.

Nirmatrelvir/Ritonavir comes as a pre-packaged course of medication. Each dose of this medication is made up of three tablets taken together: two 150 mg nirmatrelvir tablets and one 100 mg ritonavir tablet. The typical dose is 300 mg of nirmatrelvir and 100 mg of ritonavir by mouth every 12 hours for 5 days. Your dose might be different if you have kidney problems.

Nirmatrelvir/Ritonavir is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of the following apply:
History of clinically significant hypersensitivity reactions to the active ingredients (nirmatrelvir or ritonavir) or any other components. Co-administration with drugs highly dependent on CYP3A for clearance and for which elevated concentrations are associated with serious and/or life-threatening reactions.
Co-administration with potent CYP3A inducers where significantly reduced nirmatrelvir or ritonavir plasma concentrations may be associated with the potential for loss of virologic response and possible resistance.

Common side effects of Nirmatrelvir/Ritonavir:

• Changes in taste
• Diarrhea

Serious side effects are rare with Nirmatrelvir/Ritonavir. Contact your healthcare provider immediately if you experience any of the following.

• Severe allergic reaction: trouble breathing; rash; fever; swelling of the face, lips, or throat
• Liver problems: dark urine, feeling tired, upset stomach or stomach pain, yellowing of the skin or whites of the eyes

The following medications may interact with Nirmatrelvir/Ritonavir:

• Co-administration of Nirmatrelvir/Ritonavir can alter the plasma concentrations of other drugs and other drugs may alter the plasma concentrations of Nirmatrelvir/Ritonavir. Consider the potential for drug interactions prior to and during Nirmatrelvir/Ritonavir therapy and review concomitant medications during Nirmatrelvir/Ritonavir therapy

Various FDA-approved generic manufacturers

It is not known if Nirmatrelvir/Ritonavir can harm your unborn baby. Tell your healthcare provider right away if you are or if you become pregnant.

• Paxlovid