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Mircera is the brand name for methoxy polyethylene glycol-epoetin beta and is available for intravenous or subcutaneous use.

Mircera is available as a 30 mcg, 50 mcg, 75 mcg, 100 mcg, 120 mcg, 150 mcg, 200 mcg, or 250 mcg per 0.3 mL single-dose prefilled syringe and a 360 mcg per 0.6 mL single-dose prefilled syringes.

Mircera is an erythropoiesis-stimulating agent (ESA) used in the treatment of anemia associated with chronic kidney disease (CKD) in certain adult and pediatric patients.

Mircera is a type of erythropoiesis-stimulating agent (ESA) called an erythropoietin receptor activator. It attaches to the same receptor that erythropoietin does. This tells the body to make more red blood cells to help people with anemia.

Mircera is typically dosed as follows:

• For people who haven’t had treatment with an ESA before
• Adults who are on dialysis: The typical starting dose is 0.6 mcg/kg of body weight given as an injection under the skin or into the vein once every 2 weeks.
• Adults who aren’t on dialysis: The typical starting dose is 1.2 mcg/kg of body weight given as an injection under the skin once a month.
• Children ages 5 to 17 years old who are on dialysis: The dose will depend on your child’s previous ESA medication dose. Mircera is typically given as an injection into the vein once every 4 weeks.
• For people who’ve had treatment with an ESA before
• Adults only: Your Mircera dose will be based on the dose of your previous ESA therapy. Mircera is given as an injection either into a vein or under the skin, once every 2 weeks or once a month.
• Your provider will adjust your Mircera dose based on your hemoglobin levels.

Mircera is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Uncontrolled hypertension
• Pure red cell aplasia (PRCA) that begins after treatment with Mircera or other ESAs
• History of serious allergic reactions to Mircera

Common side effects of Mircera:

• High blood pressure
• Diarrhea
• Cold and flu symptoms
• Upper respiratory infection
• Headache
• Muscle spasms

Serious side effects are rare with Mircera. Contact your healthcare provider immediately if you experience any of the following:

• Blood clot: redness, swelling, or pain in one leg; chest pain; vision problems; shortness of breath; sudden confusion; trouble speaking; trouble walking; fainting
• Serious allergic or skin reaction: trouble breathing, fast heartbeat, skin rash, blistering skin, swelling in the face or throat, fever

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Vifor Pharma

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Methoxy Polyethylene Glycol-Epoetin Beta