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Methsuximide is available as a 300 mg oral capsule.

Methsuximide is an antiepileptic and is used to treat absence (petite mal) seizures, when other medications aren’t working well enough.

Methsuximide is an antiepiletic (anti-seizure) medication. It calms certain nerves and brain activity that are linked to seizures in people who have absence (petit mal) epilepsy (a condition with recurring seizures).

Methsuximide is typically dosed at 300 mg by mouth daily. If necessary, your provider will raise your dose slowly about every week until they find the right dose for you. The maximum dose is 1.2 grams (1,200 mg) total per day.

Methsuximide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Methsuximide:

• Nausea or vomiting
• Poor appetite
• Diarrhea
• Weight loss
• Stomach pain
• Constipation
• Drowsiness
• Difficulty with walking, movement, or coordination
• Dizziness
• Headache
• Blurred vision

Serious side effects are rare with Methsuximide. Contact your healthcare provider immediately if you experience any of the following.

• Low blood cell counts: getting sick more often, feeling weak or short of breath more than usual

The following medications may interact with Methsuximide:

• Since Methsuximide may interact with concurrently administered antiepileptic drugs, periodic serum level determinations of these drugs may be necessary (eg, Methsuximide may increase the plasma concentrations of phenytoin and phenobarbital)

Various FDA-approved generic manufacturers

It is not known if Methsuximide can harm your unborn baby. Tell your healthcare provider right away if you become pregnant while taking Methsuximide. You and your healthcare provider will decide if you should take Methsuximide while you are pregnant.
If you become pregnant while taking Methsuximide, talk to your healthcare provider about registering with the North American Antiepileptic Drug (NAAED) Pregnancy Registry. The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy. You can enroll in this registry by calling 1‑888‑233‑2334.

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