MesalaminePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Mesalamine
    Generic for Canasa
    30 suppositorys $26.7 USD
    Save $740.10
  3. Mesalamine DR
    Generic for Lialda
    30 delayed release tablets $37.2 USD
    Save $227.10
  4. Mesalamine Extended Release (ER)
    Generic for Apriso
    30 extended release capsules $12 USD
    Save $110.70
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Do you need a prescription for mesalamine?

Yes, mesalamine is only available with a valid physician Rx.

How much is mesalamine without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase mesalamine, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for mesalamine in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a mesalamine savings card?

Yes. Save up to 90% on your mesalamine with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a mesalamine coupon provider in the US?

No. Now Patient does not provide mesalamine coupons or FREE mesalamine samples.

Do you accept commercial, Medicare or Medicaid coverage for mesalamine in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much mesalamine?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using mesalamine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much mesalamine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic mesalamine?

Generic mesalamine refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of mesalamine

Mesalamine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of inflammatory bowel diseases, including ulcerative colitis and Crohn’s disease.

Active ingredient of mesalamine

The active ingredient of mesalamine is mesalamine, also known as 5-aminosalicylic acid (5-ASA).

US brand names of mesalamine and manufacturers

Mesalamine is available under various brand names in the US, including Asacol HD, Delzicol, Pentasa, Lialda, and Apriso. These medications are manufactured by different pharmaceutical companies.

UK brand names of mesalamine and manufacturers

In the UK, mesalamine is available under various brand names, including Asacol, Pentasa, Salofalk, and Mezavant. The manufacturers may vary depending on the brand name.

Prescription requirement for mesalamine

A prescription (Rx) is required for mesalamine in both the US and the UK.

Availability of mesalamine in the UK with NHS prescription

Mesalamine is available in the UK with an NHS prescription.

Conditions treated by mesalamine

Mesalamine is an antiinflammatory, primarily used for the treatment of ulcerative colitis, an inflammatory bowel disease that affects the lining of the colon and rectum. It may also be used in the treatment of Crohn’s disease, another type of inflammatory bowel disease that can affect any part of the digestive tract.

How does mesalamine work?

The exact mechanism of action of mesalamine is not fully understood, but it is believed to work locally in the intestine by reducing inflammation and blocking certain chemical mediators involved in the inflammatory process.

Forms of mesalamine available

Mesalamine is available in various forms, including oral delayed-release tablets, delayed-release capsules, extended-release capsules, and rectal suppositories or enemas.

Dosage of mesalamine

The dosage of mesalamine may vary depending on the specific condition being treated, the severity of the disease, and individual patient factors. It is important to follow the prescribed dosage instructions provided by the healthcare provider.

Directions for mesalamine use

Mesalamine should be taken exactly as directed by the healthcare provider. The medication may need to be taken with or without food, depending on the specific formulation. For rectal suppositories or enemas, the instructions for administration should be followed carefully.

Warnings and precautions for mesalamine

  • Mesalamine should be used with caution in individuals with known hypersensitivity to salicylates, aminosalicylates or other medications. It may cause an allergic reaction or worsen existing allergies
  • It may interact with certain medications, including blood thinners and certain antibiotics. It is important to inform the healthcare provider about all medications being taken
  • Mesalamine or sulfasalazine may cause an acute intolerance syndrome. Symptoms include stomach pain, cramping, malaise, rash, pruritis, conjunctivitis, bloody diarrhea, and fever. You should be monitored closely for worsening of any of these symptoms while using mesalamine
  • Tell your doctor if you have had kidney stones, kidney disease, liver disease, a blockage in your stomach or intestines, or eczema, before you start treatment with mesalamine

Use of mesalamine during pregnancy

The use of mesalamine during pregnancy should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider.

Use of mesalamine while breastfeeding

Mesalamine is generally considered safe to use while breastfeeding, as only minimal amounts are expected to pass into breast milk. However, consultation with a healthcare provider is necessary to assess the potential risks and benefits in individual cases.

Possible side effects of mesalamine

Common side effects of mesalamine may include headache, nausea, abdominal pain, diarrhea, and rash. Serious adverse effects are rare but can include severe allergic reactions, pancreatitis, yellowing eyes/skin, chest pain, trouble breathing and kidney problems. It is important to report any concerning symptoms to a healthcare provider.

Interactions with other drugs

Mesalamine may have drug interactions with certain other medications such as NSAIDs (ibuprofen, naproxen, diclofenac) . It is important to inform your healthcare provider about all the prescription drugs, over-the-counter treatments, vitamins and supplements you are taking to avoid potential interactions.

Similar drugs to mesalamine

Other medications used for similar conditions include azathioprine, balsalazide, corticosteroids, immunomodulators, and biologic therapies.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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