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Mepsevii is the brand name for vestronidase alfa-vjbk an is available as an intravenous infusion.

Mepsevii is available as a 10 mg/5 mL (2 mg/mL) single-dose vial.

Mepsevii is an is an enzyme replacement therapy used in pediatric and adult patients for the treatment of Mucopolysaccharidosis VII (MPS VII, Sly syndrome).

Mepsevii is a recombinant human lysosomal beta glucuronidase. It treats mucopolysaccharidosis type VII (MPS VII or Sly syndrome), a rare, genetic condition where the body doesn’t make enough of an enzyme (protein) that normally breaks down molecules called glycosaminoglycans (GAGs). The buildup of GAGs can cause problems in many parts of the body, including the bones, joints, brain, physical features, vision, and heart. Mepsevii replaces the missing enzyme in so GAGs can be broken down properly in the tissues.

The recommended dose of Mepsevii is 4 mg/kg administered every two weeks as an intravenous infusion.

Mepsevii is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Mepsevii:

• Infusion site reactions
• Diarrhea
• Rash
• Swelling
• Itching

Serious side effects are rare with Mepsevii. Contact your healthcare provider immediately if you experience any of the following:

• Severe allergic reaction: difficulty breathing, fast heartbeat, rash, hives, swelling of the face or tongue, tightness in the throat, dizziness, feeling confused, nausea, diarrhea, stomach pain

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Ultragenyx Pharmaceutical

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Vestronidase Alfa-Vjbk