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MEDICAL INFORMATION
Lynkuet Key Facts
What is Lynkuet?
Lynkuet is the brand name for elinzanetant and is available as a soft gelatin capsule for oral use. It is a non-hormonal prescription medicine and the first dual neurokinin 1 (NK1) and neurokinin 3 (NK3) receptor antagonist approved by the FDA.
What dosages is Lynkuet available in?
Lynkuet is available as 60 mg soft gelatin capsules. The recommended dose is 120 mg (two 60 mg capsules) taken orally once daily at bedtime.
What is Lynkuet used for?
Lynkuet is indicated for the treatment of moderate to severe vasomotor symptoms (VMS) due to menopause, commonly known as hot flashes. It is a non-hormonal option suitable for women who cannot or choose not to use hormone therapy.
How does Lynkuet work?
Lynkuet is a dual neurokinin 1 (NK1) and neurokinin 3 (NK3) receptor antagonist. It works by inhibiting Substance P and Neurokinin B through antagonism of NK1 and NK3 receptor signalling on kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the hypothalamus.
During menopause, falling estrogen levels cause these neurons to become overactive, disrupting the body’s temperature regulation and leading to hot flashes. By blocking both NK1 and NK3 receptors, Lynkuet helps restore normal thermoregulation, reducing the frequency and severity of hot flashes and associated sleep disturbances.
How do I take Lynkuet?
Take Lynkuet 120 mg (two 60 mg capsules) orally once daily at bedtime, at approximately the same time each day.
Take with or without food. Swallow the capsules whole with water — do not cut, crush, or chew them.
If you miss a dose at bedtime, skip it and take the next dose as scheduled the following night. Do not take two doses on the same day to make up for a missed dose.
Avoid grapefruit and grapefruit juice during treatment as it can increase the amount of Lynkuet in your blood.
Is it safe for me to take Lynkuet?
Lynkuet is a safe and effective treatment when used for its FDA-approved indication. However, like all medicines, it can cause side effects. You should discuss potential risks with your healthcare provider before starting treatment.
Before starting Lynkuet, your healthcare provider should:
• Confirm you are not pregnant
• Check your liver function with a blood test
• Repeat the liver blood test 3 months after starting treatment
Tell your healthcare provider if you have:
• Liver problems — Lynkuet is not recommended if you have moderate or severe liver impairment
• End-stage kidney disease — Lynkuet is not recommended in this setting
• A history of seizures — use with caution
• Any plans to become pregnant — Lynkuet is contraindicated in pregnancy
Lynkuet Common Side Effects
Common side effects of Lynkuet (≥2% and more frequent than placebo):
• Headache
• Fatigue
• Dizziness
• Somnolence (sleepiness)
• Abdominal pain
• Rash
• Diarrhoea
• Muscle spasms
• Nausea
• Gastroesophageal reflux disease (heartburn)
Some patients have reported mild to moderate photosensitivity (increased sensitivity to sunlight). Nervous system effects such as drowsiness, fatigue, and dizziness occurred in approximately 12% of patients in clinical trials. Patients should be cautious about driving or operating machinery until they know how Lynkuet affects them.
Lynkuet Serious Side Effects
Serious side effects are uncommon with Lynkuet but contact your healthcare provider immediately if you experience any of the following:
Liver problems (hepatic transaminase elevations): Seek medical attention if you notice new onset fatigue, decreased appetite, nausea, vomiting, itching, yellowing of skin or eyes (jaundice), pale stools, dark urine, or abdominal pain. Liver blood tests should be performed before starting treatment and at 3 months.
CNS depressant effects and daytime impairment: Somnolence, dizziness, and other nervous system effects occurred in approximately 12% of patients. Do not drive or engage in hazardous activities until these effects have resolved.
Risk of pregnancy loss: Animal studies indicate Lynkuet may cause pregnancy loss or stillbirth. It is contraindicated in pregnancy.
Seizures: Use with caution if you have a history of seizures, as one case of seizure was reported in a patient with a prior seizure history during clinical trials.
Effects of other drugs, drug classes and over-the-counter products on Lynkuet
Elinzanetant is primarily metabolised by the CYP3A4 enzyme. The following drug interactions are important:
Drugs that increase Lynkuet exposure (avoid or reduce dose):
• Strong CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, clarithromycin, ritonavir): avoid concomitant use
• Grapefruit and grapefruit juice: avoid during treatment
• Moderate CYP3A4 inhibitors (e.g. fluconazole, diltiazem, verapamil, erythromycin): reduce Lynkuet dose to 60 mg once daily
Drugs that reduce Lynkuet effectiveness (avoid):
• Strong CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin, St John’s Wort): avoid concomitant use
• Moderate CYP3A4 inducers: avoid concomitant use
Drugs affected by Lynkuet:
• Lynkuet is a weak CYP3A4 inhibitor and may increase exposure of CYP3A4 substrates. Avoid concomitant use with CYP3A4 substrates where small increases in concentration may lead to serious adverse effects.
Always tell your physician and pharmacist about all medicines, supplements (including herbal products), and vitamins you are taking.
Who makes Lynkuet?
Bayer Healthcare
Is Lynkuet safe in pregnancy?
Lynkuet is contraindicated in pregnancy. Based on animal reproduction studies, elinzanetant may cause pregnancy loss or stillbirth when administered during pregnancy. Fetal malformations were not observed in these studies.
Women of reproductive potential should:
• Have a negative pregnancy test before starting Lynkuet
• Use effective contraception during treatment and for 2 weeks after stopping
• Discontinue Lynkuet immediately if pregnancy is confirmed
Breastfeeding: There are no human data on the presence of elinzanetant in breast milk. Animal studies show elinzanetant is present in animal milk and metabolites were detected in the plasma of nursing pups. The potential risk to a breastfed infant is unknown. Discuss with your healthcare provider before breastfeeding while on Lynkuet.
What is the generic name for Lynkuet?
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
HOW IT WORKS
Order Delivery Guide


How will my order be delivered?
All orders are shipped in discreet and unmarked packaging, making them suitable for delivery to your home, workplace, or a neighbour. For your protection and safety, your first order can only be delivered to the address that is registered with NowPatient. Future orders can be delivered to any address you choose.
Where does NowPatient deliver?
NowPatient delivers to the UK, Europe, and worldwide. NHS services (such as NHS Online Pharmacy and NHS Pharmacy First) are available to patients in England only. Our private services and online pharmacy are available across the UK, with international shipping available to European and worldwide addresses. Please note that some remote or rural postcodes may experience slightly longer delivery times, and tracking availability for worldwide orders may vary depending on the destination country.
What delivery options are available?
UK orders are shipped via Royal Mail Tracked 24 & Signed, with next-day delivery as standard. European deliveries are sent via Royal Mail Tracked and typically arrive within 3–5 working days. Worldwide deliveries take 7–21 working days and are tracked where available in the destination country.
Delivery charges apply for most services. Shipping is included in the price for patients using our Get Treated Privately service in England, and is free for NHS Quit Smoking Service orders.
When will my order be dispatched?
We aim to dispatch all orders placed Monday to Friday before 3:00pm on the same working day. Orders placed after 3:00pm, or over weekends and bank holidays, will be dispatched on the next available working day.
Do you offer next-day delivery?
Yes. All UK orders are shipped via Royal Mail Tracked 24 & Signed, which delivers next day as standard. To qualify for same-day dispatch, please place your order before 3:00pm Monday to Friday. Orders placed after this time, or over weekends and bank holidays, will be dispatched on the next available working day.
Do you deliver temperature-sensitive or cold-chain medications?
Yes. We use a specialist courier service for all thermo-sensitive deliveries (such as insulin, GLP-1 weight loss injections like Mounjaro, and other refrigerated medications). Cold chain-validated packaging is used throughout the entire delivery process to ensure product quality, safety, and efficacy are always maintained.
How is cold-chain packaging handled?
Temperature-sensitive products are packed using validated cold chain packaging that maintains the required storage temperature throughout transit. Your parcel will normally receive an estimated delivery window from the courier on the day of delivery, so you can ensure someone is available to receive it. If you have concerns about receiving a cold-chain delivery, please contact our customer care team in advance.
Do you deliver controlled drugs?
Yes. Controlled drugs are delivered using a specialist courier service to ensure secure and compliant handling in accordance with UK regulations. These deliveries will always require a signature upon receipt.
How do I track my order?
Once your order has been dispatched, you will receive a dispatch notification containing your tracking details. You can also view your tracking information at any time in the 'Notification Feed' section on your account dashboard. Tracking is available for all delivery options.
Will I receive status updates about my order?
Yes. NowPatient uses a structured notification system to keep you fully informed throughout the order process. Every time your order status changes — from approval through to dispatch and delivery — you will be notified immediately. Notifications are sent via email and appear in the 'Notifications' section of your account homepage (accessible via the bell icon). This includes updates when your treatment is approved, dispensed, and shipped.
What order statuses will I see?
You can expect to see the following key status updates: Order Received, Prescription Approved (where applicable), Order Dispensed, Dispatched (with tracking reference), and Delivered.
Can I change my delivery address?
For your first order, delivery must be made to the address registered with NowPatient at the time of sign-up. This is a safety measure to verify your identity and protect your account. From your second order onwards, you can select from any saved address in your account or add a new delivery address during checkout.
Can I have my order delivered to my workplace or a neighbour?
Yes. From your second order onwards, you can have your medication delivered to any address, including your workplace, a family member's address, or a neighbour. All parcels are sent in discreet, unmarked packaging, so the contents will not be identifiable.
How do I update or add a new delivery address?
You can manage your delivery addresses directly within your NowPatient account settings. Additional addresses can also be added during the checkout process when selecting your delivery address. Simply select 'Add a new address' and enter the required details.
What should I do if my order hasn't arrived?
If you have not received your order within the expected delivery window, please first check your tracking details in the 'Notification Feed' section of your account dashboard. If after 10 days of dispatch you have still not received your delivery, please contact our customer care team and we will work to resolve the issue as quickly as possible.
What if my order arrives damaged?
If your order arrives in a damaged condition, please do not use the medication and contact our customer care team immediately. Please retain the original packaging and, if possible, take photographs of the damage, as this will help us raise a claim with the courier and arrange a replacement for you as quickly as possible.
My tracking shows delivered but I haven't received my parcel — what should I do?
First, check with any neighbours or safe locations at your property (such as a porch or outbuilding). If you still cannot locate your parcel, please contact our customer care team and we will investigate the matter with the courier on your behalf.
What happens if I miss my delivery?
If you miss a delivery, the courier will typically leave a card with instructions for rescheduling or collecting your parcel from a local depot. For cold-chain deliveries, it is particularly important to arrange redelivery promptly to maintain product integrity. If you have concerns about a missed cold-chain delivery, please contact our customer care team for guidance.
If you ship international, do I need to handle duties?
No. Our prices include customs duties, wherever you are located.
How are NHS repeat prescriptions delivered?
Once your GP has approved your prescription request, NowPatient's regulated online pharmacy will dispense and dispatch your medication. You will be notified at each stage of the process. NHS prescriptions are dispatched via Royal Mail Tracked 24 & Signed for next-day delivery, provided the order is placed before 3:00pm on a
working day.
Is delivery free for NHS prescriptions?
No. There is a small cost applied to all NHS prescription deliveries. This allows us to keep our service operational. NHS Quit Smoking Service orders qualify for free delivery. If you are using the Get Treated Privately service in England, shipping is included within the consultation and treatment price.
Can I specify a preferred delivery date for my NHS prescription?
At this time, NowPatient dispatches orders on the same working day if placed before 3:00pm Monday to Friday. All UK NHS prescriptions are sent via Royal Mail Tracked 24 & Signed for next-day delivery, so you can plan accordingly once you receive your dispatch notification.
How are private prescription medications delivered after a telehealth consultation?
Following your telehealth or video consultation, if a treatment is prescribed, it will be added to your cart automatically. After you complete checkout and payment, your order is sent to NowPatient's regulated online pharmacy for processing. You will receive status updates at every stage and your medication will be dispatched in discreet, unmarked packaging.
How quickly will I receive medication after my consultation?
If your consultation and checkout are completed before 3:00pm on a working day, we aim to dispatch your medication the same day. The total time to delivery will depend on the delivery method you select at checkout.
Is the packaging discreet?
Yes. All NowPatient orders are shipped in plain, unmarked packaging with no branding or indication of the contents on the outside. The packaging is suitable for delivery to your home, workplace, or a neighbour.
Will my parcel require a signature?
Yes. All UK orders are sent via Royal Mail Tracked 24 & Signed, which requires a signature upon delivery. Controlled drug deliveries will always require a signature regardless of the shipping method. For cold-chain deliveries, a signature is required to ensure someone is available to receive the medication promptly and maintain product integrity. For European and worldwide orders, signature requirements may vary depending on the destination country and the service available.
How do I contact NowPatient about a delivery issue?
You can reach our customer care team through the NowPatient website or app. Go to your account and use the Help or Contact Us section to raise a query. Our team is available to assist with any delivery-related concerns including missing parcels, tracking queries, or delivery address changes.
What are NowPatient's customer care hours?
Please visit the Contact Us section of the NowPatient website or app for up-to-date information on our customer care operating hours and available contact methods.
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