LUMAKRAS
Used for Cancer
Are you tired of high medication costs? Our service offers unbeatable savings on your LUMAKRAS prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by Amgen Inc.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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LUMAKRAS key facts
What is LUMAKRAS?
LUMAKRAS is the brand name for sotorasib oral tablets.
What dosages is LUMAKRAS available in?
LUMAKRAS is available as a 120 mg and 320 mg oral tablet.
What is LUMAKRAS used for?
LUMAKRAS is a KRAS G12C inhibitor and is used to treat metastatic non-small cell lung cancer (NSCLC) with a KRAS G12C mutation, after having tried at least one previous cancer treatment.
How does LUMAKRAS work?
LUMAKRAS is a KRAS G12C inhibitor. KRAS is a protein in your body that sends signals to your cells to grow and divide. In certain lung cancers, a mutation (change) in KRAS called G12C leads to uncontrolled cell growth. LUMAKRAS attaches to KRAS proteins with the G12C mutation. By doing so, the medication helps block tumor growth.
How do I take LUMAKRAS?
The typical dose is 960 mg by mouth once a day, with or without food. LUMAKRAS is available as 120 mg and 320 mg tablets. The daily dose is taken as eight 120 mg tablets or three 320 mg tablets at one time each day.
Is it safe for me to take LUMAKRAS?
LUMAKRAS is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
LUMAKRAS Common Side Effects
Common side effects of LUMAKRAS:
- Diarrhea
- Muscle or bone pain
- Fatigue
- Nausea
- Cough
LUMAKRAS Serious Side Effects
Serious side effects are rare with LUMAKRAS. Contact your healthcare provider immediately if you experience any of the following.
- Liver injury: pain in the right side of the stomach, yellowing of the eyes or skin, dark or brown urine
- Lung damage: cough, shortness of breath, fever
Effects of other drugs, drug classes and over-the-counter products on LUMAKRAS
The following medications may interact with LUMAKRAS:
- Coadministration of LUMAKRAS with gastric acid-reducing agents decreased sotorasib concentrations which may reduce the efficacy of sotorasib. Avoid coadministration of LUMAKRAS with proton pump inhibitors (PPIs), H2 receptor antagonists, and locally acting antacids. If coadministration with an acid-reducing agent cannot be avoided, administer LUMAKRAS 4 hours before or 10 hours after administration of a locally acting antacid
LUMAKRAS is a CYP3A4 substrate. Coadministration of LUMAKRAS with a strong CYP3A4 inducer decreased
- sotorasib concentrations , which may reduce the efficacy of sotorasib. Avoid coadministration of LUMAKRAS with strong CYP3A4 inducers
Sotorasib is a P-gp inhibitor. Coadministration of LUMAKRAS with a P-gp substrate increased its plasmaconcentrations, which may increase the adverse reactions of the substrate. Avoid coadministration of LUMAKRAS with P-gp substrates, for which minimal concentration changes may lead to serious toxicities. If coadministration cannot be avoided, decrease the P-gp substrate dosage in accordance with its Prescribing Information.
Sotorasib is a BCRP-inhibitor. Coadministration of LUMAKRAS with a BCRP substrate increased its plasma
- concentrations, which may increase the risk of adverse reactions of the substrate. When coadministered with LUMAKRAS, monitor for adverse reactions of the BCRP substrate and decrease the BCRP substrate dosage in accordance with its Prescribing Information
Who makes LUMAKRAS?
Amgen Inc.
Is LUMAKRAS safe in pregnancy?
It is not known if LUMAKRAS may harm your unborn baby. Talk to your healthcare provider about possible pregnancy and birth control choices that are right for you.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my LUMAKRAS prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your LUMAKRAS prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient LUMAKRAS savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient LUMAKRAS savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for LUMAKRAS | Canadian Prescription Savings* for LUMAKRAS | LUMAKRAS Drug Coupon* | LUMAKRAS Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of LUMAKRAS?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for LUMAKRAS | Canadian Prescription Savings* for LUMAKRAS | LUMAKRAS Drug Coupon* | LUMAKRAS Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the LUMAKRAS savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the LUMAKRAS drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for LUMAKRAS, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the LUMAKRAS prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, LUMAKRAS is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed LUMAKRAS for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the LUMAKRAS prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the LUMAKRAS prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for LUMAKRAS
If you are having trouble paying for your LUMAKRAS medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for LUMAKRAS you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- LUMAKRAS is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers LUMAKRAS
- If LUMAKRAS is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for LUMAKRAS
If you are having trouble paying for your LUMAKRAS medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for LUMAKRAS you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers LUMAKRAS
- If LUMAKRAS is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for LUMAKRAS
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your LUMAKRAS treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for LUMAKRAS you will need to meet the following criteria:
- You must be currently insured and have coverage for LUMAKRAS
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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