LUMAKRAS
Used for Cancer
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Manufactured by Amgen Inc.
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LUMAKRAS Uses, Side Effects, Interactions, Warnings & Dosing
What is LUMAKRAS?
LUMAKRAS is the brand name for sotorasib oral tablets.
What dosages is LUMAKRAS available in?
LUMAKRAS is available as a 120 mg and 320 mg oral tablet.
What is LUMAKRAS used for?
LUMAKRAS is a KRAS G12C inhibitor and is used to treat metastatic non-small cell lung cancer (NSCLC) with a KRAS G12C mutation, after having tried at least one previous cancer treatment.
How does LUMAKRAS work?
LUMAKRAS is a KRAS G12C inhibitor. KRAS is a protein in your body that sends signals to your cells to grow and divide. In certain lung cancers, a mutation (change) in KRAS called G12C leads to uncontrolled cell growth. LUMAKRAS attaches to KRAS proteins with the G12C mutation. By doing so, the medication helps block tumor growth.
How do I take LUMAKRAS?
The typical dose is 960 mg by mouth once a day, with or without food. LUMAKRAS is available as 120 mg and 320 mg tablets. The daily dose is taken as eight 120 mg tablets or three 320 mg tablets at one time each day.
Is it safe for me to take LUMAKRAS?
LUMAKRAS is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
LUMAKRAS Common Side Effects
Common side effects of LUMAKRAS:
- Diarrhea
- Muscle or bone pain
- Fatigue
- Nausea
- Cough
LUMAKRAS Serious Side Effects
Serious side effects are rare with LUMAKRAS. Contact your healthcare provider immediately if you experience any of the following.
- Liver injury: pain in the right side of the stomach, yellowing of the eyes or skin, dark or brown urine
- Lung damage: cough, shortness of breath, fever
Effects of other drugs, drug classes and over-the-counter products on LUMAKRAS
The following medications may interact with LUMAKRAS:
- Coadministration of LUMAKRAS with gastric acid-reducing agents decreased sotorasib concentrations which may reduce the efficacy of sotorasib. Avoid coadministration of LUMAKRAS with proton pump inhibitors (PPIs), H2 receptor antagonists, and locally acting antacids. If coadministration with an acid-reducing agent cannot be avoided, administer LUMAKRAS 4 hours before or 10 hours after administration of a locally acting antacid
LUMAKRAS is a CYP3A4 substrate. Coadministration of LUMAKRAS with a strong CYP3A4 inducer decreased
- sotorasib concentrations , which may reduce the efficacy of sotorasib. Avoid coadministration of LUMAKRAS with strong CYP3A4 inducers
Sotorasib is a P-gp inhibitor. Coadministration of LUMAKRAS with a P-gp substrate increased its plasmaconcentrations, which may increase the adverse reactions of the substrate. Avoid coadministration of LUMAKRAS with P-gp substrates, for which minimal concentration changes may lead to serious toxicities. If coadministration cannot be avoided, decrease the P-gp substrate dosage in accordance with its Prescribing Information.
Sotorasib is a BCRP-inhibitor. Coadministration of LUMAKRAS with a BCRP substrate increased its plasma
- concentrations, which may increase the risk of adverse reactions of the substrate. When coadministered with LUMAKRAS, monitor for adverse reactions of the BCRP substrate and decrease the BCRP substrate dosage in accordance with its Prescribing Information
Who makes LUMAKRAS?
Amgen Inc.
Is LUMAKRAS safe in pregnancy?
It is not known if LUMAKRAS may harm your unborn baby. Talk to your healthcare provider about possible pregnancy and birth control choices that are right for you.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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