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Kazano is the brand name for alogliptin and metformin and is available as an oral tablet.

Kazano is available as an oral tablet that contains one of the following:
12.5 mg alogliptin and 500 mg metformin HCl
12.5 mg alogliptin and 1000 mg metformin HCl

Kazano is a DDP-4 inhibitor / Biguanide and is used to treat type 2 diabetes in adults.

Kazano is a combination of two medications. Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by blocking DPP-4, a protein that breaks down certain hormones in your body. These hormones normally tell your body to make more insulin and produce less sugar. When DPP-4 causes these hormone levels to drop, you end up having high blood sugar levels. By blocking the action of DPP-4, alogliptin helps your body produce more insulin and make less sugar. In doing so, alogliptin helps lower your blood sugar levels. Metformin is a biguanide that lowers blood sugar in several ways. It lowers the amount of sugar that your liver makes. It also makes your body more sensitive to the effects of insulin. When your body is able to use insulin better, it can move more blood sugar into your cells to use as energy. In addition, metformin lowers the amount of sugar that gets absorbed through your intestines. As a result of these three pathways, metformin helps lower the amount of sugar in your bloodstream.

Kazano is typically dosed as 12.5 mg/500 mg (alogliptin / metformin) by mouth twice daily with food. The maximum dose is 12.5 mg/1000 mg (alogliptin / metformin) twice daily.

Kazano is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in any of the following:
Severe renal impairment: eGFR below 30 mL/min/1.73 m2.
Metabolic acidosis, including diabetic ketoacidosis.
History of serious hypersensitivity to alogliptin or metformin, components of Kazano or any of the excipients.

Common side effects of Kazano:

• Upper respiratory tract infection or common cold symptoms
• Diarrhea
• Higher blood pressure
• Headache
• Back pain
• Urinary tract infection symptoms

Serious side effects are rare with Kazano. Contact your healthcare provider immediately if you experience any of the following.

Buildup of lactic acid: confusion, feeling weak, fast or slow heartbeat, rapid breathing, no appetite, nausea, vomiting
Inflamed pancreas: upper stomach pain, fever, nausea, vomiting
Serious liver problems: feeling tired or weak, poor appetite, losing weight without trying, dark urine, eyes and skin turning more yellow, upper right stomach pain
Severe skin or allergic reactions: rash, blisters, sores, trouble breathing, swelling

The following medications may interact with Kazano:

• Carbionic anhydrase inhibitors may increase risk of lactic acidosis.
• Consider more frequent monitoring.
• Drugs that reduce metformin clearance (such as ranolazine
• vandetanib, dolutegravir, and cimetidine), may increase the
• accumulation of metformin. Consider the benefits and risks of
• concomitant use.
• Alcohol can potentiate the effect of metformin on lactate metabolism.
• Warn patients against excessive alcohol intake.

Takeda Pharmaceuticals

It is not known if Kazano will harm your unborn baby. Talk with your
doctor about the best way to control your blood sugar while you are pregnant or if you plan to become pregnant.

• Alogliptin/Metformin